Month: February 2021

120737-78-2, tert-Butyl 2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 7-(3,4-dimethoxyphenyl)-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridine-2- carbaldehyde (for a preparation see Intermediate 25, 100 mg, 0.304 mmol) in DCM (5 mL) was added acetic acid (0.026 mL, 0.455 mmol) and ierf-butyl 2-methylpiperazine-1 -carboxylate (0.073 mL, 0.364 mmol) and the reaction mixture was stirred under nitrogen at room temperature for one hour. Sodium triacetoxyborohydride (322 mg, 1.518 mmol) was then added and the reaction was refluxed under nitrogen overnight. The reaction mixture was allowed to cool to room temperature and was then hydrolyzed with a saturated aqueous solution of sodium bicarbonate (20 mL). The layers were separated and the aqueous phase was extracted with DCM (3 x 10 mL). The combined organic layers were washed with a saturated aqueous solution of sodium chloride solution (approx. 20 mL), dried over magnesium sulphate, filtered and concentrated under vacuum to give a light brown residue. The residue was purified by chromatography on silica gel eluting with 0 to 5% MeOH in DCM. The appropriate fractions were combined to give an impure light brown residue. The product was therefore loaded onto a 2g SCX column and was flushed with MeOH (3 column volumes). The product was eluted in 2.0M ammonia in MeOH (3 column volumes) and concentrated to give ferf-butyl 4-((7-(3,4-dimethoxyphenyl)-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2- yl)methyl)-2-methylpiperazine-1-carboxylate (1 10 mg, 71 % yield) as a yellow oil. LCMS (2 min, Formic Acid): Rt = 0.90 min, MH+ = 514, 120737-78-2

120737-78-2 tert-Butyl 2-methylpiperazine-1-carboxylate 15087784, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; GLAXOSMITHKLINE LLC; AMANS, Dominique; BAMBOROUGH, Paul; BIT, Rino, Antonio; BROWN, John, Alexander; CAMPBELL, Matthew; LINDON, Matthew, John; SHIPLEY, Tracy, Jane; THEODOULOU, Natalie, Hope; WELLAWAY, Christopher, Roland; WESTAWAY, Susan, Marie; WO2014/78257; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

120737-78-2, tert-Butyl 2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a greenhouse test tube was added rac-benzyl ((2S,3R,4R)-1-acetyl-6-bromo-2-cyclopropyl-3- methyl-I ,2,3,4-tetrahydroq uinolin-4-yl)carbamate (for a preparation see Intermediate 3, 101 mg,0.234 mmol), sodium tert-butoxide (65 mg, 0.676 mmol), DavePhos (18.1 mg, 0.046 mmol),Pd(dba)3 (21.9 mg, 0.024 mmol) and 1,4-dioxane (2 mL). tert-Butyl 2-methylpiperazine-1- carboxylate (0.070 mL, 0.351 mmol) was then added and the reaction mixture stirred at 100 C for 20 h 45 mm. The reaction mixture was allowed to cool to rt and then filtered through a pad of celite and rinsed with ethyl acetate. The filtrate was concentrated and purified by MDAP (Formic) to give the product (14.1 mg, 0.034 mmol, 14.46%) as a pale yellow gum. This was a racemic mixture ofdiatereoisomers. LCMS (2 mm Formic): Rt = 0.77 mi [MH] = 417.

120737-78-2, The synthetic route of 120737-78-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; AMANS, Dominique; ATKINSON, Stephen John; HARRISON, Lee Andrew; HIRST, David Jonathan; LAW, Robert Peter; LINDON, Matthew; PRESTON, Alexander; SEAL, Jonathan Thomas; WELLAWAY, Christopher Roland; WO2014/140076; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.262368-30-9,N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide,as a common compound, the synthetic route is as follows.

General procedure: To a suspension of methyl (Z)-1-acetyl-3-(ethoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate (6) (500 mg,1.368 mmol) in DMF (3.5 mL) was added N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide (14) (395 mg,1.505 mmol, 1.1 equiv.) at RT. After heating the reaction mixture at 80 C for 1 h, it was allowed to cool to RT. Piperidine (297 lL,3.010 mmol, 2.2 equiv.) was then added and stirred for 2 h. Volatiles were removed in vacuo and water was added to the obtained residue and stirred for 15 min. The precipitate was then filtered under suction and cake was washed with water, then with minimum amount of cold methanol, and then ether. The obtained product was purified by column chromatography (neutral Al2O3,0-10% methanol in CH2Cl2) to afford 532 mg (72%) of target molecule 15., 262368-30-9

The synthetic route of 262368-30-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Edupuganti, Ramakrishna; Taliaferro, Juliana M.; Wang, Qiantao; Xie, Xuemei; Cho, Eun Jeong; Vidhu, Fnu; Ren, Pengyu; Anslyn, Eric V.; Bartholomeusz, Chandra; Dalby, Kevin N.; Bioorganic and Medicinal Chemistry; vol. 25; 9; (2017); p. 2609 – 2616;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5308-25-8,1-Ethylpiperazine,as a common compound, the synthetic route is as follows.,5308-25-8

General procedure: A solution of compound 2 (0.55 mmol), 1-substituted piperazine (0.83 mmol) and pyridine (0.8 mmol) in 10 mL THF (tetrahydrofuran) was stirred at room temperature overnight. When the reaction was completed, the solvent was evaporated under reduced pressure. The residues were dissolved in ethyl acetate and washed with water and saturated sodium chloride solution. After drying over anhydrous Na2SO4, the solvent was removed under reduced pressure to get crude product. The pure products were obtained by recrystallizing from ethanol.

The synthetic route of 5308-25-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wu, Zhilin; Ding, Na; Tang, Yuting; Ye, Jiao; Peng, Junmei; Hu, Aixi; Research on Chemical Intermediates; vol. 43; 8; (2017); p. 4833 – 4850;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5294-61-1, N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Part C. Synthesis of N-(2,6-dimethylphenyl)-2-[4-(2-chloroacetyl)piperazinyl]acetamide (9) To a solution of 5 (1g, 4mmol) in 15ml THF was added chloroacetic anhydride (0.692g, 4mmol). The solution was heated to reflux for one hour. The solvent was evaporated in vacuo and the residue was purified using flash chromatography to yield compound 9., 5294-61-1

Big data shows that 5294-61-1 is playing an increasingly important role.

Reference£º
Patent; Blackburn, Brent K.; Zablocki, Jeff; Elzein, Elfatih; Nudelman, Grigory; US2001/44541; (2001); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.162046-66-4,4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)benzoic acid,as a common compound, the synthetic route is as follows.

Example 36 Preparation of N -(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-yl)-4-(piperazin-1-yl) benzamide hydrochloride To a solution of 4-(4-(tert-butoxycarbonyl)piperazin-1-yl)benzoic acid (commercial) (109 mg,357 flmol) in N,N-dimethylformamide (1.00 ml) under nitrogen at room temperature, wereadded HA TU ( 0-(7-azabenzotriazol-1-yl)-N ,N ,N’ ,N’-tetramethyluronium hexafluorophosphate)(204 mg, 536 flmol) and N-ethyldiisopropylamine (185 mg, 243 f..Ll, 1.43 mmol). After 5 minutesstirring at room temperature, 8-fluoro-2-methyl-imidazo[1,2-a]pyridin-6-ylamine hydrochloride (Example B.4) (72 mg, 357 flmol) was added. The mixture was stirred at room temperature for21 hours and then at 60C for 2 hours. The solvent was removed in vacuo. The residue was taken in a saturated aqueous solution of bicarbonate and extracted three times with ethyl acetate. The combined extracts were dried over sodium sulfate, filtered and concentrated in vacuo. The crude oil was purified on silica gel (Eluent: heptane/ethyl acetate 0 to 10%) to provide 78 mg of tert-butyl 4-(4-(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-ylcarbamoyl)phenyl)piperazine-1-carboxylate. To a suspension of this compound (40 mg, 88.2 flmol) in methanol (400 f..Ll) was added HC14M in dioxane (221 f..Ll, 882 flmol). The light yellow suspension was stirred at roomtemperature for 17 hours. The solid was filtered, washed with ether and hexane and dried toprovide 25 mg (72.7 %) of the title compound as a light yellow solid., 162046-66-4

162046-66-4 4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)benzoic acid 2795508, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; PTC THERAPEUTICS INC.; DAKKA, Amal; GREEN, Luke; KARP, Gary; NARASIMHAN, Jana; NARYSHKIN, Nikolai; PINARD, Emmanuel; QI, Hongyan; RATNI, Hasane; RISHER, Nicole; WEETALL, Marla; WOLL, Matthew; WO2014/209841; (2014); A2;,
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Piperazines – an overview | ScienceDirect Topics

129799-15-1, Methyl 1-Boc-piperazine-2-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 6-bromo-4,7-dichloroquinazoline (300 mg, 1.08 mmol), tert-butyl methyl piperazine-1,2-dicarboxylate (395 mg, 1.62 mmol), DIEA (836 mg, 6.48 mmol) in 1,4-dioxane (8 mL) was stirred at 80C for 1 h. The mixture was allowed to cool to RT, quenched with saturated NaHCO3 solution and then extracted with ethyl acetate. The organic layer was washed with brine, dried over Na2SO4, filtered and concentrated in vacuo. The residue was purified by flash column chromatography onsilica gel (ethyl acetate/petroleum ether = 1:5) to afford the desired product (367 mg,70% yield) as a white solid., 129799-15-1

As the paragraph descriping shows that 129799-15-1 is playing an increasingly important role.

Reference£º
Patent; ARAXES PHARMA LLC; JANES, Matthew, Robert; PATRICELLI, Matthew, Peter; LI, Liansheng; REN, Pingda; LIU, Yi; (397 pag.)WO2016/44772; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

109384-27-2, 1-Methylpiperazin-2-one hydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

N-(ira^-4-(3-Chloropyrazin-2-yloxy)cyclohexyl)benzo[JJthiazol-2-amine (0.080 g, 0.22 mmol), 1 -methylpiperazin-2-one hydrochloride (0.10 g, 0.67 mmol), and triethylamine (0.093 mL, 0.67 mmol) were mixed in DMSO (2 mL) under an argon atmosphere. The reaction mixture was stirred at 80 C for 24 h. The reaction mixture was then warmed to 120 C and stirred for an additional 72 h. The reaction mixture was cooled to T, diluted with water, and extracted with EtOAc (2x). The organic extracts were combined, washed with saturated sodium chloride, dried over magnesium sulfate, filtered, and concentrated. The resulting crude product was purified via silica gel chromatography to give 4-(3-(ira?s-4-(benzo[J]thiazol-2- ylamino)cyclohexyloxy)pyrazin-2-yl)-l-methylpiperazin-2-one as a light orange solid. [M+l] 439.2. ICso (uM): 0.5369., 109384-27-2

109384-27-2 1-Methylpiperazin-2-one hydrochloride 17060766, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; AMGEN INC.; ALLEN, Jennifer; FROHN, Michael; HARRINGTON, Paul; PICKRELL, Alexander; RZASA, Robert; SHAM, Kelvin; HU, Essa; WO2011/143366; (2011); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.132710-90-8,1-Boc-4-(3-hydroxypropyl)piperazine,as a common compound, the synthetic route is as follows.,132710-90-8

A mixture of tert-butyl 4-(3-hydroxypropyl)piperazine-l-carboxylate (1.52 g, 6.2 mmol), Ph3P (2.46 g, 9.4 mmol), I2 (2.40 g, 9.4 mmol) and imidazole (1.28 g, 18.6 mmol) in DCM (100 mL) was stirred at room temperature for 5 h. The mixture was diluted with DCM and the organic layer was washed with brine, dried over anhydrous sodium sulfate, filtered, and evaporated under vacuum to give a residue which was purified by column chromatography (silica gel, PE : EtOAc = 5 : 1) to afford tert-butyl 4-(3-iodopropyl)piperazine-l-carboxylate (1.10 g, 50% ) as a colorless oil.

The synthetic route of 132710-90-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PRINCIPIA BIOPHARMA INC.; BRAMELD, Kenneth Albert; VERNER, Erik; (122 pag.)WO2016/191172; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103-76-4,N-(2-Hydroxyethyl)piperazine,as a common compound, the synthetic route is as follows.

For the N-boc protection of amines, to solution of diboc (1 mmol) in ethanol (5 ml) was added {K*18-crown-6]Br3}n (0.001 mmol). The solution was stirred at room temperature for 1 min. The amine (1 mmol) was then added and solution as stirred at room temperature for an appropriate time (table 1). After completion of the reaction, the solvent was removed by water bath distillation. To the residue was added ethyl acetate (5 ml) and the mixture was filtered (the catalyst is insoluble in n-hexane and ethyl acetate). The solid was washed with ethyl acetate ()10 ml*2) amd combined filtrates were reduced to dryness to yield the pure products.

103-76-4, 103-76-4 N-(2-Hydroxyethyl)piperazine 7677, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Chehardoli, Gholamabbas; Zolfigol, Mohammad Ali; Derakhshanpanah, Fateme; Cuihua Xuebao/Chinese Journal of Catalysis; vol. 34; 9; (2013); p. 1730 – 1733;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics