Month: January 2021

13484-40-7, 1-(2-Methoxyethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 2 To a solution of (S)-3-cyano-3-({(1R,2S)-2-[(1-methyl-1H-indole-2-carbonyl)-amino]-cyclohexanecarbonyl}-amino)-propyl ester (223 mg, 0.484 mmol) in anhydrous DMF (2.0 ML) was added 1-(2-methoxyethyl)-piperizine (214 mg, 1.48 mmol), and the reaction mixture was placed in a 69 C. oil bath for 22 hours.The cooled reaction mixture was partitioned between water (75 ML) and ethyl acetate (75 ML).The organic layer was separated, washed with water (2*75 ML), dried with sodium sulfate, filtered, concentrated, and purified by column chromatography (5:95, MeOH/CH2Cl2) to give 173 mg (70%) of 1-methyl-1H-indole-2-carboxylic acid ((1S,2R)-2-{(S)-1-cyano-3-[4-(2-methoxy-ethyl)-piperazin-1-yl]-propylcarbamoyl}-cyclohexyl)-amide as an amorphous solid. MS: 509 (M+H+)., 13484-40-7

13484-40-7 1-(2-Methoxyethyl)piperazine 2734638, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Bamberg, Joe Timothy; Gabriel, Tobias; Krauss, Nancy Elisabeth; Mirzadegan, Taraneh; Palmer, Wylie Solang; Smith, David Bernard; US2004/77646; (2004); A1;,
Piperazine – Wikipedia
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170911-92-9, tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

tert-butyl 4-(4-aminophenyl)piperazine-1-carboxylate (1.12 g, 4.03 mmol) was added to a stirred solution of ethyl 2-chloro-8-methyl-5-oxo-5,8-dihydropyrido [2, 3-d]pyrimidine-6-carboxylate (1.08 g, 4.03 mmol) in DMF (10.0 mL) in a 50mL RB flask. The reaction mixture was heated at 100 C. After 1 h, the reaction mixture was allowed to cool to RT and a precipitate formed that was collected by filtration and washed with methanol to give the title compound (1.75 g, 85%) as a bright yellow solid. LCMS (Method A) : RT =1.25 mi m/z = 509 [M+H].

170911-92-9, As the paragraph descriping shows that 170911-92-9 is playing an increasingly important role.

Reference£º
Patent; ALMAC DISCOVERY LIMITED; ROUNTREE, James Samuel Shane; O’DOWD, Colin Roderick; BURKAMP, Frank; BELL, Mark Peter; WO2015/19037; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

74879-18-8, (S)-(+)-2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

74879-18-8, In a sealed tube, 7-fluoro-9-methyl-2-(2-methylimidazo [1 ,2-b]pyridazin-6-yl)pyrido [1,2- a]pyrimidin-4-one (Intermediate 3; 250 mg, 0.808 mmol), and (S)-2-methylpiperazine (405 mg,4.04 mmol, 5.0 eq.) were stuffed in DMSO (6 mL) and heated at 130C overnight. The solvent was removed under high vacuum. The residue was taken up in CH2C12 and washed with an aqueous saturated solution of NaHCO3. The organic layer was separated and dried over Na2504 and concentrated in vacuo. The crude was purified by column chromatography (5i02, CH2C12/MeOH=95/5 to 85/15) to afford the title product (135 mg, 43%) as a light yellow solid.MS m/z 390.3 [M+H?i.

The synthetic route of 74879-18-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; ALSENZ, Jochem; GRASSMANN, Olaf; KUEHL, Peter; METZGER, Friedrich; MCCARTHY, Kathleen Dorothy; MORAWSKI VIANNA, Eduardo Paulo; WOODHOUSE, Marvin Lloyd; (130 pag.)WO2017/80967; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21043-40-3, 1-Cyclopentylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a mixture of intermediate 7 (500 mg, 1.3 mmol), EDC¡¤HCl (300 mg, 1.5 mmol) and HOBt (210 mg, 1.5 mmol)) in dried CH2Cl2 was added appropriate amine (1.5 mmol), and stirred at rt for overnight. After complete reaction, the reaction mixture was concentrated in vacuo and purified via column chromatography to afford appropriate 2-(2-(tritylamino)thiazol-4-yl)acete amide. The above product was dissolved in the mixture of 5 mL of acetic acid and 0.1 mL of water. The solution was heated under argon at 60 C for 1 h, and then allowed to cool to rt. The resulted dark solution was diluted with 20 mL of water, the triphenylmethanol was removed by extraction with Et2O. The watery phase was adjusted to pH8 with saturated Na2CO3 solution, and extracted with CH2Cl2. The organic extract was dried over anhydrous MgSO4, evaporated to dryness in vacuo. The resulting brown oil was purified via column chromatography with CH2Cl2-MeOH as eluent to afford appropriate 2-(2-(amino)thiazol-4-yl)acete amide 8a-f., 21043-40-3

The synthetic route of 21043-40-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Sang, Chun-Yan; Tian, Heng-Zhi; Chen, Yue; Liu, Jian-Fei; Chen, Shi-Wu; Hui, Ling; Bioorganic and Medicinal Chemistry Letters; vol. 28; 2; (2018); p. 71 – 76;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

109-01-3, 1-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

109-01-3, 1-METHYLPIPERAZINE (13.49 g, 135 mmol) and triethylamine (16.4 g, 162 mmol) were added to 200 mL OF CHC13 in a 500 mL round-bottomed flask equipped with a 250 mL addition funnel under argon with a magnetic stirring bar. 4-nitrobenzoyl chloride (25.00 g, 135 mmol) was dissolved in 200 mL OF GHCI3 with slight warming. The solution of benzoyl chloride was placed in the addition funnel and was added slowly to the solution of piperazine. The solution warmed slightly and was allowed to stir 1 hour after the addition was complete. The reaction was concentrated until the product began to precipitate. The product was isolated by vacuum filtration and rinsed with two 25 mL portions of cold diethyl ether. After recrystallization from 95% ethanol, the product, 4-METHYL-1- (4- nitrobenzoyl) piperazine, was pure by standard analytical techniques.

As the paragraph descriping shows that 109-01-3 is playing an increasingly important role.

Reference£º
Patent; SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH; WO2004/63195; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1235865-77-6,2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4′-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid,as a common compound, the synthetic route is as follows.

4- (4-oxaspiro [2.4] heptan-6-yloxy) -3-nitrobenzenesulfonamide (0.2 g, 0.64 mmol, 1 eq)2 – ((1H-pyrrolo [2,3-b] pyridin-5-yl) oxy) -4- (4 – ((4′-chloro-5,5-dimethyl- , 6-tetrahydro- [1,1′-biphenyl] -2-yl) methyl) piperazin-1-yl) benzoic acid(0.147 g, 0.77 mmol, 1.2 eq), DMAP (0.234 g, 1.92 mmol, 3 eq), 10 mL & lt; RTI ID = 0.0 & gt;DCM was placed in a one-necked flask and stirred at 0 C for half an hour before reacting at room temperature,The reaction was complete with the addition of 5 mL of water, quenching the reaction, separating the organic phase, drying, column chromatography, EA: DCM (v / v) = 1: 1 to give 0.2 g of product as a yield of 35%., 1235865-77-6

1235865-77-6 2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4′-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid 66713100, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Sunshine Lake Pharma Co.,Ltd.; Kou, Yuhui; Hu, Bolin; Jiang, Haigang; Ye, Jiuyong; Liu, Zhiqiang; Xie, Hongming; Zhang, Yingjun; (42 pag.)CN106565706; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103-76-4,N-(2-Hydroxyethyl)piperazine,as a common compound, the synthetic route is as follows.

5mmol N,N-dimethylglycine,2mmol CuI,20mmol 4,6-dichloro-2-methylpyrimidine is soluble100 mL of N,N-dimethylformamide (DMF),22 mmol of N-hydroxyethylpiperazine was added with stirring.40mmol K3PO4, stir at room temperature for 40min,22 mmol of 2-amino-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide was added with stirring.Passing N2 and reacting at 120 C for 6 h,The copper salt was dissolved in 50 mL of aqueous ammonia, and extracted with 50 mL of EtOAc (EtOAc).The crude product was added to 100 mL of an 80% aqueous ethanol solution, and stirred.2 g of activated carbon was added, refluxed for 30 min, filtered while hot, and the filtrate was recrystallized overnight, filtered, and the filter cake was washed with ice-cold 80% aqueous ethanol solution and dried.That is, 8.64 g of a white solid was obtained, the yield was 88.41%, and the purity was 99.92%.

103-76-4, The synthetic route of 103-76-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shandong Luoxin Pharmaceutical Group Co., Ltd.; Shandong Luoxin Pharmaceutical Group Hengxin Pharmaceutical Co., Ltd.; Shandong Yuxin Pharmaceutical Co., Ltd.; Gao Hongjun; Ren Qingwei; Zhang Qingdong; (12 pag.)CN109879869; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

154590-35-9, tert-Butyl 4-(4-amino-2-fluorophenyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

154590-35-9, To a solution of 4-(4-Amino-2-fluoro-phenyl)-piperazine-1 -carboxylic acid te/t-butyl ester (1.00 g, 3.4 mmol) and 2-pyhd-3-yl benzoic acid (0.70 g, 3.7 mmol) in DMF (10 ml_) was added HATU (1.42 g, 3.7 mmol) and diisopropylamine (0.65 ml_, 3.7 mmol). After stirring at room tempertaure for 18 h, the reaction mixture was diluted with EtOAc (100 ml_) and washed with H2O (4×50 ml_). The organic extracts were combined, dried (Na2SO4), and the solvent was evaporated under reduced pressure. Chromatography of the resulting residue (SiO2: EtOAc:Hex) yielded 4-[2-fluoro-4-(2-pyridin-3-yl- benzoylamino)-phenyl]-piperazine-1 -carboxylic acid te/t-butyl ester which was further dissolved in MeOH (20 ml_) and 4N HCI in dioxanes. After stirring for 5 h, the reaction mixture was concentrated down, neutralized with 1 N NaOH, and extracted with EtOAc (3x75ml_). The organic extracts were combined, dried (Na2SO4), and the solvent was evaporated under reduced pressure to yield the title compound.MS: mass calcd. for C22H21FN4O, 376.17; m/z found, 378.4 [M+H]+

154590-35-9 tert-Butyl 4-(4-amino-2-fluorophenyl)piperazine-1-carboxylate 16203630, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; JANSSEN PHARMACEUTICA, N.V.; WO2009/6185; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.120737-59-9,tert-Butyl 3-methylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

(a) te?^-Butyl 4-(3-cyano-5-(ethoxycarbonyl>6-methylpyridin-2-yl)-3-methylpiperazine- 1-carboxylate; Ethyl 6-chloro-5-cyanonicotinate (0.500 g, 2.4 mmol), tert-butyl 3-methylpiperazine-1- carboxylate (0.480 g, 2.40 mmol), and DIPEA (0.41 mL, 2.40 mmol) were dissolved in DMF (4 mL) and heated at 100 ¡ãC for 8 h. The reaction mixture was cooled to room temperature and the solvent concentrated under reduced pressure. The material was partitioned between EtOAc (50 mL) and saturated aqueous NaHCO3 (2 x 30 mL). The organics were washed with EPO brine (30 mL), dried (Mg5O4) and concentrated under reduced pressure to afford the crude product. No purification was done., 120737-59-9

The synthetic route of 120737-59-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; WO2006/73361; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57260-71-6,tert-Butyl piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.,57260-71-6

EXAMPLE 125 N-Boc-N-bromoacetyl-piperazine The title compound was prepared as described above for N-bromoacetyl-N(bis-Boc-guanidinyl)piperazine from N-Boc-piperazine (prepared as per the procedure of Carpino, L.A., et al., J. Org. Chem., 1983, 48, 661-665) (23.0 g, 123 mmol), bromoacetyl bromide (25.0 g, 123 mmol), and diisopropyletyhl amine (21 mL, 156 g, 120 mmol) in 240 mL of CH2Cl2. Flash chromatographic purification afforded 25.0 g of the title compound as pale yellow crystals, yield 66%. Silica gel TLC Rf 0.34 (1:1 hexanes-EtOAc). 1H NMR delta1.37 (s, 9H), 3.30-3.56 (m, 8H), 3.80 (s, 2H). 13C NMR delta25.8, 28.2, 28.5, 41.9, 43.2, 46.5, 80.3, 154.4, 165.4. MS (FAB) m/z 331 (M+Na)+. HRMS (FAB) m/z 307.066 (M+H)+(C11H20BrN2O3 requires 307.065). Anal. Calcd. for C:LHlgBrN2O3: C, 43.01; H, 6.22; N, 9.12. Found: C, 43.24; H, 6.22; N, 9.37.

The synthetic route of 57260-71-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ISIS Pharmaceuticals, Inc.; US6329523; (2001); B1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics