Month: January 2021

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21655-48-1,cis-2,6-Dimethylpiperazine,as a common compound, the synthetic route is as follows.

Preparation 8:1-[3-((3R,5S)-3,4,5-TrimethyI-pperazin-1-yI)-phenyl]-ethanone; STEP A; An oven-dried MW tube was charged with Pd2(dba)3 (592 mg, 0.65 mmol), K3PO4 (1.92 g, 9.06 mmol) and (2′-dicyclohexylphosphanyl-biphenyl-2-yl)-dimethyl-amine (127 mg, 0.32 mmol). The tube was purged and backfilled with N2 and then 1-(3- chloro-phenyl)-ethanone (1 g, 6.47 mmol), (2R,6S)-2,6-dimethyl-piperazine (886 mg, 7.76 mmol) and DME (10 ml) were added. The mixture was heated in a MW apparatus for 4 h at 1000C and then further Pd2(dba)3 (592 mg, 0.65 mmol) and (2′-dicyclohexylphosphanyl-biphenyl-2-yl)-dimethyl-amine (127 mg, 0.32 mmol) were added. The reaction mixture was heated to 1000C for additional 10 h and then the solid was filtered off over a Celite pad. The filtrate was diluted with AcOEt and extracted with 1 M HCI. The aqueous phase was brought to basic conditions with NH4OH and extracted with AcOEt. The organic phase was dried over Na2SO4 and evaporated in vacuo. The crude reaction mixture was purified by column chromatography (eluent: AcOEt/MeOH 8:2) to give 226 mg of 1-[3-((3R,5S)-3,5- dimethyl-piperazin-1-yl)-phenyl]-ethanone. Y= 15percent

21655-48-1, The synthetic route of 21655-48-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; DAC S.R.L.; WO2007/113249; (2007); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31166-44-6,1-Cbz-Piperazine,as a common compound, the synthetic route is as follows.

To a suspension of Intermediate 10A (50 mg, 0.17 mmol) and Pd2(dba)3 (15 mg, 0.017 mmol) in toluene (2 mL) was added Xantphos (29 mg, 0.050 mmol), benzyl piperazine-l-carboxylate (37 mg, 0.17 mmol), followed by sodium tert-butoxide (48 mg, 0.50 mmol). The reaction mixture was stirred at 70 ¡ãC for 16 h, and then filtered. The filtrate was concentrated and purified by flash chromatography using a 15 min gradient from 0 to 100percent EtOAc in hexanes to give Intermediate 10B (70 mg, 0.16 mmol, 96percent yield). LC-MS (ESI) m/z 440.1 (M+H), RT = 2.27 min (Method B).

31166-44-6, As the paragraph descriping shows that 31166-44-6 is playing an increasingly important role.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; HU, Carol Hui; QIAO, Jennifer X.; WANG, Tammy C.; WO2013/151923; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21655-48-1, cis-2,6-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a sealed tube, 7-fluoro-9-methyl-2-(2-methyl-[l,2,4]triazolo[l,5-b]pyridazin-6-yl)-4H- pyrido[l,2-a]pyrimidin-4-one (Intermediate (VT3), 30 mg, 0.097 mmol), TEA (48.9 mg, 67.4 mu, 0.483 mmol, 5 eq.) and (2S,6R)-2,6-dimethylpiperazine (33.1 mg, 0.290 mmol, 3 eq.) were stirred in DMSO (1.5 ml) at 120¡ãC for 24 hours. The crude was purified by column (0428) chromatography (Si02, DCM/MeOH=90/10) to afford the title product (30 mg, 76percent) as a brown solid. MS m/z 405.3 [M+H]+.

21655-48-1, The synthetic route of 21655-48-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; GILLESPIE, Robert Jack; HASANE, Ratni; SARIE, Jerome Charles; (89 pag.)WO2016/184832; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5747-48-8, 11-(Piperazin-1-yl)dibenzo[b,f][1,4]thiazepine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5747-48-8, ll-Piperazin-l-yldibenzo[b,f][l,4]thiazepine was screened for potential salt formation with 30 acids listed below in Table 1. Stock solutions (0.05 M) of each of the acids were prepared in methanol. A stock solution (0.05 M) of amorphous 11-piperazin-l- yldibenzo[b,f][l,4]thiazepine (free base) was also prepared. A 150 muL aliquot of free base solution was mixed with a 150 muL aliquot of each of the acid solutions in individual wells of a glass 96-well plate. Each combination was prepared in duplicate. The methanol was allowed to evaporate either at room temperature (rt) or at 50 0C. Each well was then viewed microscopically at a magnification of 4Ox initially, under crossed-polars, to determine the nature (crystalline or non-crystalline) of any solid material that was formed.A 300 muL aliquot of another solvent (either acetone, acetonitrile or ethyl acetate) was added to each well. The plate was then sonicated to re-dissolve the solid material, followed by storage at room temperature or 50 C, allowing evaporation of solvent. Each well was then viewed microscopically at a magnification of 4Ox initially, under crossed-polars, to determine the nature (crystalline or non-crystalline) of any solid material that was formed. Results are shown in Table 1. The symbol “A” indicates formation of solid amorphous particles/film. The symbol “B” indicates formation of amorphous cake. The symbol “C” indicates formation of ciystalline particles. The symbol “P” indicates precipitation after mixing and formation of crystalline particles.Table 1

As the paragraph descriping shows that 5747-48-8 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; WO2007/62336; (2007); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5308-25-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5308-25-8,1-Ethylpiperazine,as a common compound, the synthetic route is as follows.

Under nitrogen protection, 4-fluorobenzoic acid methyl ester (3.0 mL, 20.69 mmol) was dissolved in 20 mL DMSO,K2CO3 (5.718 g, 41.38 mmol) was added sequentially,N-ethylpiperazine (1.93 mL, 24.83 mmol). 120 C overnight,The reaction was cooled to room temperature, and the mixture was partitioned between ethyl acetate and saturated brine (50 mL). The aqueous layer was extracted with ethyl acetate (50 mL ¡Á 3), and the combined organic layers were washed with saturated sodium chloride,Dried over anhydrous sodium sulfate,The solvent was distilled off under reduced pressure, and the residue was subjected to silica gel column chromatography (dichloromethane / methanol = 10/1) to obtain 4.405 g of a white solid, yield 85.8%.

5308-25-8 1-Ethylpiperazine 79196, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Fudan University; Shanghai Institute of Materia Medica, Chinese Academy of Sciences; Li, Yingxia; Geng, Meiyu; Liu, Jing; Ding, Jian; Zhang, Wei; Ai, Jing; (20 pag.)CN106032359; (2016); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

55121-99-8, (4-Aminophenyl)(4-methylpiperazin-1-yl)methanone is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

55121-99-8, 4-(4-(4-methyl piperazine-1-carbonyl) phenyl) amino-6- […] (intermediate 1-c) weighing 4-chloro-6- […] (1-a, 0 . 16g, 0.58mmol) in isopropanol (5 ml), add 4-(4-methyl piperazine-1-carbonyl) aniline (0.14g, 0 . 64mmol), to reflux temperature under nitrogen for 5h, cooling to room temperature, filter, the white solid obtained 1-c (0.18g, 73%).

As the paragraph descriping shows that 55121-99-8 is playing an increasingly important role.

Reference£º
Patent; Xi’an Jiaotong University; Xin, Minghang; Zhang, Sanqi; Zhang, Hao; Xie, Xiaoxiao; Hei, Yuanyuan; Zuo, Saijie; Mao, Shuai; (40 pag.)CN105237484; (2016); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.118753-66-5,tert-Butyl 4-aminopiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.,118753-66-5

The compound 4-chloro-5-nitro-1-p-toluenesulfonyl-1H-pyrrolo [2,3-b] pyridine (1.18 g, 5.87 mmol), N, N-diisopropylethylamine (7.10 g, 55mmol)And 1-Boc-4-aminopiperazine (1.18 g, 5.87 mmol) were added to 60 mL of isopropanol (suspension), and the temperature was raised to 100 C. with stirring under nitrogen for 16 hours.After the reaction was completed, the mixture was cooled to room temperature, ether was added, and a large amount of a yellow solid precipitated.Filtration, collection of solids and drying1-Boc-4-((5-nitro-1-p-toluenesulfonyl-1H-pyrrolo [2,3-b] pyridin-4-yl) amino) piperazine (2.16 g, yield 76%) .

As the paragraph descriping shows that 118753-66-5 is playing an increasingly important role.

Reference£º
Patent; Weimou Bio-technology (Shanghai) Co., Ltd.; Shen Wang; Liu Pengfei; Bai Rujun; Liu Yufei; Luo Qiuping; Ke Pingbo; Gong Yanchuan; (71 pag.)CN110483514; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

163765-44-4, (R)-1-Boc-3-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

163765-44-4, The (R) – 1-BOC-3-methyl-piperazine (300 mg, 1 . 5mmol) dissolved in acetonitrile (10 ml) in, adding DIEA (390 mg, 3mmol) and 3,3-dimethoxy dibutyl-propyl bromide (258 mg, 1 . 73mmol), 50 C reaction 2d, cessation of the reaction, the reaction liquid concentrated, column chromatography (DCM: MeOH=60 the […] the 1 – – 50 […] 1) to get the yellow oily 300 mg, yield 75%.

163765-44-4 (R)-1-Boc-3-Methylpiperazine 2756811, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Institute Of Materia Medica Chinese Academy Of Medical Sciences; Xu, Bailing; Chen, Xiaoguang; Yao, Haiping; Ji, Ming; Jin, Jing; Zhou, Jie; Wang, Ke; Zhao, Dalong; (55 pag.)CN105461697; (2016); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

50606-32-1, Butyl piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50606-32-1, Example 33: (lalpha,5alpha,6beta)-3-{6-[2-(4-Butoxycarbonyl-piperazin-l-yl)-2-oxo- ethylcarbamoyl]-2-phenyl-pyrimidin-4-yl}-3-aza-bicyclo[3.1.0]hexane-6-carboxylic acid:33.1 4-(2-tert-Butoxycarbonylamino-acetyl)-piperazine-l-carboxylic acid butyl ester:To a solution of Boc-Glycine (2351 mg) in DCM (150 mL) were added HOBT hydrate (2358 mg) and EDCI hydrochloride (3100 mg) and the mixture was stirred for 30 min at RT. Intermediate 1.4 (2500 mg) was then added and the reaction mixture was stirred at RT overnight. A IN NaHStheta4 aqueous solution was added to the mixture, the formed solid was filtered off and the 2 phases of the filtrate were separated. The org. phase was washed with sat. Na2CO3 solution, dried (MgSO^ and evaporated off to afford 4620 mg of the desired compound as white solid. LC-MS: tR = 0.92 min; [M+H]+: 344.27.

As the paragraph descriping shows that 50606-32-1 is playing an increasingly important role.

Reference£º
Patent; ACTELION PHARMACEUTICALS LTD; CAROFF, Eva; HILPERT, Kurt; HUBLER, Francis; MEYER, Emmanuel; RENNEBERG, Dorte; WO2010/116328; (2010); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

163765-44-4, (R)-1-Boc-3-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(c) (R)-4-[5-(4-Bromo-2-fluoro-5-trifluoromethoxy-phenylcarbamoyl)-pyridin-2-yl]-3-methyl-piperazine-1-carboxylic acid tert-butyl ester The solid from the previous step was dissolved in a mixture of N,N-diisopropylethylamine (3 mL, 20 mmol) and DMSO (3 mL) and (R)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester (2.2 g, 11 mmol) was added. The reaction mixture was heated at 120 C. overnight, concentrated by rotary evaporation, dissolved in a small amount of DCM, and purified by silica gel chromatography (0-40% ethyl acetate:hexanes) to produce the title intermediate as a white solid (3.6 g, 80% yield). (m/z): [M+H]+ calcd for C23H25BrF4N4O4 577.10; 579.10. found 577.5, 580.3., 163765-44-4

The synthetic route of 163765-44-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; LONG, Daniel D.; MCKINNELL, Robert Murray; JIANG, Lan; LOO, Mandy; LEPACK, Kassandra; VAN ORDEN, Lori Jean; OGAWA, Gavin; HUANG, Xiaojun; ZHANG, Weijiang; US2013/115194; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics