With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.208167-83-3,tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
Into a 25-mL sealed tube purged and maintained under an inert atmosphere of nitrogen, was placed a solution of 6-methoxy-2-[4-[3-(piperidin-4-yloxy)azetidin-l-yl]phenyl]-l,3-benzothiazole (110 mg, 0.28 mmol, 1 equiv), K2CO3(115 mg, 0.83 mmol, 3 equiv), ter/-butyl-4-(2- chloroethyl)piperazine-l-carboxylate (69 mg, 0.28 mmol, 1 equiv), and Nal (4.2 mg, 0.03 mmol, 0.1 equiv) in CH3CN (5 mL). The resulting mixture was stirred for 16 hours at 40 C. The solids were filtered off, and the filtrate was concentrated. The residue was applied onto a silica gel column eluting with dichloromethane/methanol (10:1). This resulted in 178 mg of tert-butyl-4-[2-[4-([l-[4-(6-methoxy-l,3- benzothiazol-2-yl)phenyl] azetidin-3 -yl] oxy)piperidin- 1 -yl] ethyl Ipiperazine- 1 -carboxylate as a yellow- green solid.
208167-83-3, As the paragraph descriping shows that 208167-83-3 is playing an increasingly important role.
Reference£º
Patent; ARVINAS OPERATIONS, INC.; CREW, Andrew P; DONG, Hanqing; BERLIN, Michael; SPARKS, Steven M.; (513 pag.)WO2020/41331; (2020); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics