161357-89-7, 1-(Methylsulfonyl)piperazine hydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 5 This Example illustrates the preparation of (R or S) N- (3- [4- methanesulphonylpiperazinyl]-3-phenylpropyl)-4- [2- (4-fluorophenylsulphonyl) ethyl] – piperidine (Compound 14, Table III). A solution of (R or S) N- (3-chloro-3-phenylpropyl)-4- [2- (4-fluorophenylsulphonyl)- ethyl] -piperidine (Method F; 310 mg) in dichloromethane (6 ml) was added to N- methanesulphonyl-piperazine hydrochloride (150 mg) followed by triethylamine (313)-D). The mixture was stirred for 48 hours, diluted with dichloromethane (5 ml) and MP-carbonate resin (1.34g), PS-ISOCYANATE resin (682 mg) and PS-thiophenol resin (577 mg) were added. The mixture was stirred for 5 hours, filtered and the resins were washed with 10% methanol in dichloromethane (2×25 ml). The combined filtrates were evaporated to dryness and the residue was passed through a 20g Isolute column eluted with a solvent gradient of ethyl acetate-10% methanol/ethyl acetate to give the title compound, yield 81 mg; MH+ 552. NMR (CDCL3) : 1.12-1. 32 (m, 4H), 1.52-1. 66 (m, 4H), 1.76-1. 93 (m, 3H), 2.08 (m, 1H), 2.21 (m, 1H), 2.47-2. 51 (m, 4H), 2.71 (s, 3H), 2.77-2. 88 (m, 2H), 3.03-3. 10 (m, 2H), 3.12-3. 21 (m, 4H), 3.37 (m, 1H), 7.14 (d, 2H), 7.15-7. 32 (m, 5H), 7.88 (m, 2H)., 161357-89-7
161357-89-7 1-(Methylsulfonyl)piperazine hydrochloride 16265612, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; ASTRAZENECA AB; WO2004/56773; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics