With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5521-39-1,2-(4-(4-Aminophenyl)piperazin-1-yl)ethanol,as a common compound, the synthetic route is as follows.,5521-39-1
30 mg of the 7-chloro-3-(2,4-dichloropyridin-3-yl)-4-imino-l-methyl-3,4- dihydropyrimido[4,5-rf]pyrimidin-2(lH)-one obtained in Production Example 2, and 16 mg of TsOH monohydrate were added to a 5-ml n-butanol solution containing 18.6 mg of 2-[4-(4- aminophenyl)piperazin-l-yl]ethanol, and the mixture was heat stirred for 15 minutes at 100C. The reaction mixture was concentrated under reduced pressure, and purified by basic column chromatography. As a result, 21 mg of a white solid was obtained as a subject compound. iH-NMR (400 MHz, CD3OD) delta: 8.97 (IH, s), 7.60-7.46 (5H, m), 7.00 (2H, d, J = 8.8 Hz), 3.76(2H, br s), 3.61 (3H, s), 3.24 (4H, br), 2.76 (4H, br s), 2.64 (2H, br). ESI-MS Found: m/z[M+H] 542
5521-39-1 2-(4-(4-Aminophenyl)piperazin-1-yl)ethanol 767100, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; BANYU PHARMACEUTICAL CO.,LTD.; BAMBA, Makoto; FURUYAMA, Hidetomo; SAKAMOTO, Toshihiro; SUNAMI, Satoshi; TAKAHASHI, Keiji; YAMAMOTO, Fuyuki; YOSHIZUMI, Takashi; WO2010/67886; (2010); A1;,
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