With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.169447-70-5,(S)-tert-Butyl 2-methylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
To a solution of 1 ,1-dimethylethyl (2S)-2-methyl-1-piperazinecarboxylate (1.5g, 7.5 mmol) in anhydrous DCM (3OmL) was added triethylamine (2.59ml_, 19 mmol) and phenyl-isocyanate (0.814ml_, 7.5 mmol) the mixture was stirred under an argon atmosphere at room temperature for 2hours. The reaction was evaporated and the residue was suspended DCM (3OmL) which was washed with (0.5M, aq) HCI (10OmL), and then water (10OmL). The collected organic layer was dried (MgSO4), filtered and evaporated to yield the title compound (1.96g, 82%)1H NMR (CDCI3) 51.21 (3H, d, J=6.8Hz), 1.48 (9H, s), 3.07 (1 H, br m), 3.20 (1 H, m), 3.30 (1 H, dd, J=13.37, 4.17Hz), 3.72 (1 H, m), 3.90 (2H, m), 4.28 (1 H, br m), 6.36 (1 H, NH, br m), 7.05 (1 H, m), 7.30 (2H, m), 7.35 (2H, m)., 169447-70-5
As the paragraph descriping shows that 169447-70-5 is playing an increasingly important role.
Reference£º
Patent; GLAXO GROUP LIMITED; BESWICK, Paul, John; CAMPBELL, Alister; CRIDLAND, Andrew; GLEAVE, Robert, James; PAGE, Lee, William; WO2010/102663; (2010); A1;,
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