With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1235865-77-6,2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4′-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid,as a common compound, the synthetic route is as follows.
4- (4-oxaspiro [2.4] heptan-6-yloxy) -3-nitrobenzenesulfonamide (0.2 g, 0.64 mmol, 1 eq)2 – ((1H-pyrrolo [2,3-b] pyridin-5-yl) oxy) -4- (4 – ((4′-chloro-5,5-dimethyl- , 6-tetrahydro- [1,1′-biphenyl] -2-yl) methyl) piperazin-1-yl) benzoic acid(0.147 g, 0.77 mmol, 1.2 eq), DMAP (0.234 g, 1.92 mmol, 3 eq), 10 mL & lt; RTI ID = 0.0 & gt;DCM was placed in a one-necked flask and stirred at 0 C for half an hour before reacting at room temperature,The reaction was complete with the addition of 5 mL of water, quenching the reaction, separating the organic phase, drying, column chromatography, EA: DCM (v / v) = 1: 1 to give 0.2 g of product as a yield of 35%., 1235865-77-6
1235865-77-6 2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4′-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid 66713100, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; Sunshine Lake Pharma Co.,Ltd.; Kou, Yuhui; Hu, Bolin; Jiang, Haigang; Ye, Jiuyong; Liu, Zhiqiang; Xie, Hongming; Zhang, Yingjun; (42 pag.)CN106565706; (2017); A;,
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