169447-70-5, (S)-tert-Butyl 2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of 1 ,1 -dimethylethyl (2S)-2-methyl-1-piperazinecarboxylate(100 mg, 0.5 mmol) in CH2CI2 (5 ml_) was mixed with 3-bromo benzaldehyde (0.06 ml_, 0.5 mmol) and NaB(OAc)3H (0.16 g, 0.75 mmol). The resulting mixture was stirred for 12 hours, diluted with dichloromethane (30 ml_) and washed with brine (50 ml_). The organic layer was collected, dried over Na2SO4 and concentrated. Separation via a combiflash system then afforded the title compound (150 mg, 81%): LC/MS: m/z, 369 (M+H); 1HNMR (MeOD) delta 1.26 (3H, d), 1.47 (9H, s), 2.0 (1 H, m), 2.1 (1 H, m), 2.6 (1 H, m), 2.8 (1 H, m), 3.1 (1 H, m), 3.3 (2H, s), 3.4 (1 H, m), 3.5 (1 H, m), 3.8 (1 H, m), 4.2 (1 H, m), 4.88 (1 H, s), 7.25 (1 H, m), 7.3 (1 H, m), 7.4 (1 H, m), 7.55 (1 H, s).
169447-70-5, The synthetic route of 169447-70-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GLAXO GROUP LIMITED; WO2006/55553; (2006); A2;,
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