With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55121-99-8,(4-Aminophenyl)(4-methylpiperazin-1-yl)methanone,as a common compound, the synthetic route is as follows.
[00307] In a microwaver vial containing 2,6-dichioro-nicotinamide (150.00 mg; 0.79 mmol;1.00 eq.) and (4-amino-phenyl)- (4-methyl-piperazin- 1 -yl)-methanone (206.64 mg; 0.94 mmol;1.20 eq.) was added THF (10.00 ml; 123.43 mmol; 157.18 eq.) and sodiumbis(trimethylsilyl)amide (2.30 ml; 2.36 mmol; 3.00 eq.) at -78C. The reaction was stuffed at rt for 1 .5h before it was quenched with lmL sat. NH4C1 solution and extracted with EtOAc (5mL X 3). The combined organic layers were combined, concentrated and carried to the next step. MS:mlz = 374 [M+H]+
55121-99-8, As the paragraph descriping shows that 55121-99-8 is playing an increasingly important role.
Reference£º
Patent; MERCK PATENT GMBH; QIU, Hui; CALDWELL, Richard D.; NEAGU, Constantin; MOCHALKIN, Igor; LIU-BUJALSKI, Lesley; JONES, Reinaldo; TATE, Devon; JOHNSON, Theresa L.; GARDBERG, Anna; WO2015/61247; (2015); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics