Brief introduction of 182181-38-0

182181-38-0, As the paragraph descriping shows that 182181-38-0 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.182181-38-0,3-Fluoro-4-(piperazin-1-yl)benzonitrile,as a common compound, the synthetic route is as follows.

Combine 1-(4-cyano-2-fluorophenyl)piperazine (1.57 g, 7.6 mmol) and Et3N (1.28 ml, 9.2 mmol) in CH2Cl2 (10 ml) and add Boc2O (1.67 g, 7.6 mmol). Stir 1 h wash with satd. NaHCO3. Dry (MgSO4) and concentrate to obtain the crude carbamate as a yellow solid.

182181-38-0, As the paragraph descriping shows that 182181-38-0 is playing an increasingly important role.

Reference£º
Patent; Schering Corporation; US2005/239795; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics