21655-48-1, cis-2,6-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
In a sealed tube, 7-fluoro-9-methyl-2-(2-methyl-[l,2,4]triazolo[l,5-b]pyridazin-6-yl)-4H- pyrido[l,2-a]pyrimidin-4-one (Intermediate (VT3), 30 mg, 0.097 mmol), TEA (48.9 mg, 67.4 mu, 0.483 mmol, 5 eq.) and (2S,6R)-2,6-dimethylpiperazine (33.1 mg, 0.290 mmol, 3 eq.) were stirred in DMSO (1.5 ml) at 120¡ãC for 24 hours. The crude was purified by column (0428) chromatography (Si02, DCM/MeOH=90/10) to afford the title product (30 mg, 76percent) as a brown solid. MS m/z 405.3 [M+H]+.
21655-48-1, The synthetic route of 21655-48-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; GILLESPIE, Robert Jack; HASANE, Ratni; SARIE, Jerome Charles; (89 pag.)WO2016/184832; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics