With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.
General procedure: Compound 6 (1mmol) was dissolved in freshly distilled dichloromethane (5mL) under nitrogen atmosphere. Then HOBt (1.1mmol), EDC,HCl (1.1mmol) were added to it. The reaction mixture was stirred for 5min, secondary amine 7a-l (1.2mmol) was added in a slow stream and followed by the addition of triethylamine (2mmol) and the reaction mixture was stirred for 24hat room temperature. The progress of the reaction was monitored by TLC. After completion of the reaction, water (10mL) was added to the reaction mixture and extracted with dichloromethane. Organic layer was collected and dried over anhydrous Na2SO4. After filtration, the solvent was removed under reduced pressure and the crude product was purified by silica gel chromatography using an eluent of 50% ethyl acetate in hexane., 30459-17-7
The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Banu, Saleha; Bollu, Rajitha; Bantu, Rajashaker; Nagarapu, Lingaiah; Polepalli, Sowjanya; Jain, Nishant; Vangala, Radhika; Manga, Vijjulatha; European Journal of Medicinal Chemistry; vol. 125; (2017); p. 400 – 410;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics