With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57260-71-6,tert-Butyl piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
To a stirred solution of tert-butyl piperazine-l-carboxylate 4 (1 g, 5.38 mmol) in CH2C12 (15 mL) at 0 C, were added 2-bromoacetyl bromide (864 mg, 4.3 mmol) and TEA (1 mL, 7.53 mmol). The reaction mixture was warmed to RT and stirred for 4 h. The mixture was quenched with water (50 mL) and extracted with CH2C12 (2 x 40 mL). The combined organic extracts were washed with brine (20 mL), dried (Na2S04), filtered and concentrated under reduced pressure. The crude was purified (silica gel; eluting 25% EtOAc/ hexanes) to afford compound 2 (900 mg, 54%) as pale yellow solid. 1H MR (500 MHz, DMSO-i): delta 4.16 (s, 2H), 3.47-3.42 (m, 4H), 3.38-3.35 (m, 2H), 3.31-3.29 (m, 2H), 1.41 (s, 9H); LC-MS (ESI): m/z 328.1 (M+ + Na)., 57260-71-6
As the paragraph descriping shows that 57260-71-6 is playing an increasingly important role.
Reference£º
Patent; PHARMAKEA, INC.; ROWBOTTOM, Martin W.; HUTCHINSON, John Howard; CALDERON, Imelda; (202 pag.)WO2016/144703; (2016); A1;,
Piperazine – Wikipedia
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