With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31166-44-6,1-Cbz-Piperazine,as a common compound, the synthetic route is as follows.
General procedure: To a 0.25 M solution of 28 (1.0 eq.) in DMF, secondary amine (1.2 eq.), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (1.2 eq.), and HOBt.H2O (1.2 eq.) were added. The mixture was stirred at room temperature for 16 hours, then poured into water (20 x DMF volume), and extracted with EtOAc (x3). The combined organic layer was washed with brine, and dried over anhydrous Na2SO4. After evaporation, the resulting residue was purified by silica gel chromatography (MeOH/CHCl3) to afford the product.
31166-44-6, As the paragraph descriping shows that 31166-44-6 is playing an increasingly important role.
Reference£º
Article; Nakano, Hirofumi; Hasegawa, Tsukasa; Imamura, Riyo; Saito, Nae; Kojima, Hirotatsu; Okabe, Takayoshi; Nagano, Tetsuo; Bioorganic and Medicinal Chemistry Letters; vol. 26; 9; (2016); p. 2370 – 2374;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics