With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.76003-29-7,1-Boc-3-Oxopiperazine,as a common compound, the synthetic route is as follows.,76003-29-7
Intermediate 721 ,1 -Dimethylethyl 4-[(4-bromophenyl)methyl]-3-oxo-1 -piperazinecarboxylateTo a solution of 1 ,1 -dimethylethyl 3-oxo-1 -piperazinecarboxylate (500 mg, 2.497 mmol) in Nu,Nu-dimethylformamide (DMF) (8 mL) at room temperature under nitrogen was added sodium hydride (60% w/w in mineral oil, 120 mg, 3.00 mmol) and the resulting suspension was stirred at this temperature for 30 min. 1 -Bromo-4-(bromomethyl)benzene (749 mg, 3.00 mmol) in DMF ( 5 mL) was then added via syringe. The resulting mixture was stirred at room temperature for 1.5 h then partitioned between AcOEt and water. The layers were separated and the aqueous phase was extracted three times with AcOEt. The combined organic phases were washed three times with brine, dried over MgS04 and concentrated in vacuo. Purification of the residue by SP4 using a 25 G silica cartridge (gradient: 13 to 63% AcOEt in Hexanes) gave 1 ,1 -dimethylethyl 4-[(4-bromophenyl)methyl]-3-oxo-1 – piperazinecarboxylate (763 mg, 2.066 mmol, 83 % yield) as an oil which solidified to a white solid over 16 h. LCMS (method A): Retention time 1.14 min, [M+H]+ = 370.95 (1 Br)
76003-29-7 1-Boc-3-Oxopiperazine 3157178, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; GLAXOSMITHKLINE LLC; DEMONT, Emmanuel, Hubert; GARTON, Neil, Stuart; GOSMINI, Romain, Luc, Marie; HAYHOW, Thomas, George, Christopher; SEAL, Jonathan; WILSON, David, Matthew; WOODROW, Michael, David; WO2011/54841; (2011); A1;,
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