Month: December 2020

20327-23-5, 1-Cyclopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

11311] 1-Cyclopropylpiperazine (268, 1.76 g, 14.0 mmol) was dissolved in 15 mE DMF. To it were added 1 -fluoro-4- nitrobenzene (1.00 g, 7.0 mmol) and DIEA (1.24 mE, 7.0 mmol). The mixture was stirred at 90 C. for overnight, cooled to RT, diluted with EtOAc, washed with water x2, dried, concentrated in vacuo, subjected to silica flash colunm using 0 to 40% EtOAc in DCM to isolate 1-cyclopropyl-4- (4-nitrophenyl)piperazine (269). It was dissolved in 2:1 EtOAc/MeOR (80 mE/40 mE), and to it were added 40 IL 6N HC1 and 10% Pd/C (0.5 g). The mixture was stirred at RT for overnight under a hydrogen balloon. It was filtered through celite, concentrated in vacuo to dryness to afford 4-(4-cyclo- propylpiperazin-1 -yl)aniline hydrochloride (270, 1.30 g, 73% overall) as an off-white solid., 20327-23-5

The synthetic route of 20327-23-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; JIA, Zhaozhong J.; CHEN, Wei; THOMAS, William D.; US2015/158865; (2015); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.314741-40-7,(S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

314741-40-7, Step D: tert-butyl (3S)-4-[2-(3-cyano-4-fluoro-2-methoxyphenyl)-2-hydroxyethyll -3- (hydroxymethyl)piperazine- 1 -carboxylate: 6-Fluoro-2-methoxy-3- (oxiran-2-yl)benzonitrile (1.4 g, 7.3 mmol) and (S)-4-N-BOC-2-hydroxymethylpiperazine (3.13 g, 14.5 mmol) were suspendedin ethanol (15 mL) then heated in a microwave apparatus for 60 mm at 150 C. The reaction mixture was cooled and evaporated to dryness. The residue was purified by chromatography through a 40g Redi-sep column and eluting with 5%MeOH/95% EtOAc to yield the title compound: LC-MS: M+1= 410;

As the paragraph descriping shows that 314741-40-7 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; PASTERNAK, Alexander; DEJESUS, Reynalda, Keh; FRIE, Jessica, L.; PIO, Barbara; TANG, Haifeng; WALSH, Shawn, P.; WO2014/99633; (2014); A2;,
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57260-71-6, tert-Butyl piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Boc-pyridazine (compound F-1, 0.558 g, 3 mmol) was weighed in 10 mL of anhydrous CH2Cl2 in a 25 mL beaker and anhydrous Na2CO3 (0.848 g, 8 mmol) was weighed into 7 mL of deionized water. Pour into a 100 mL single-mouth bottle and stir it in an ice bath for 20 min. Dissolve bromoacetyl bromide (0.568 mL, 6.6 mmol) in 10 mL of anhydrous CH2C12 and quickly drip into a single-mouth flask. Add DMAP (36.7 mg) after the addition. 0.3 mmol), stirring continued, TLC traces until starting material conversion, transfer to room temperature reaction 1 h. Extract with CH2C12 (3 X 30 mL). Combine the organic layers and dry over anhydrous Na2SO4. Chromatographic separation of CH2Cl2/MeOH=60:1, v/ nu) 598 mg (Compound G-1) was obtained as a milky white solid, yield 65%.

57260-71-6, 57260-71-6 tert-Butyl piperazine-1-carboxylate 143452, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; East China University of Science and Technology; Qian Xuhong; Xu Yufang; Jia Xiaotong; Zhu Weiping; Yang Youjun; (14 pag.)CN107619397; (2018); A;,
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115619-01-7, 4-(4-Ethylpiperazin-1-yl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a stirred solution of compound 7, 8, or 9 (1 equiv) in 1-butanol was added compounds 12(1.1 equiv) and p-toluenesulfonic acid (1 equiv). The mixture was placed in a pressure flask, and heated to 100C for 15h. The reaction mixture was quenched by saturated Na2CO3 aqueous solution, and then was extracted with DCM and the organic phase was washed with water, dried over anhydrous Na2SO4. The combined organic layer was concentrated under reduced pressure and was further purified by flash column chromatography using dichloromethane/methanol as eluent to afford product H1-H14, Y1-Y14, or L1-L14 as a pale yellow solid., 115619-01-7

The synthetic route of 115619-01-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Hou, Yunlei; Zhu, Liangyu; Li, Zhiwei; Shen, Qi; Xu, Qiaoling; Li, Wei; Liu, Yajing; Gong, Ping; European Journal of Medicinal Chemistry; vol. 163; (2019); p. 690 – 709;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115619-01-7,4-(4-Ethylpiperazin-1-yl)phenylamine,as a common compound, the synthetic route is as follows.

Step 2: A mixture of above intermediate (125 mg, 0.61 mmol), 4-(4-Ethylpiperazine-l- yl))aniline (200 mg, 0.61 mmol), and DIPEA (0.27 ml, 1.52 mmol) in DMSO (3.0 ml) was stiired at 100 C for 2 h, then at room temperature forovernight. TLC was checked and the reaction was completed. The mixture was added to water/sat. NH4C1 (50 ml/50ml) and stirred at room temperature for 30 min. The pH odf the mixture was adjusted to ~ 6 using 2N HC1. Cooled at 4 C and the solids were collected by filtration, washed by water to give the sticky fine crude product. The crude product was dissolved into DCM/MeOH(2ml/2ml), dried over sodium sulfate and concentrated. The crude product was purified on column (0-10% MeOH in DCM) to give the desired product as yellow solids (103 mg, 34% yield). 1H NMR (400 MHz, DMSO-de) delta 11.32 (br, 1H), 10.49 (br, 1H), 8.93 (s, 1H), 8.12 (s, 1H), 7.36 (d, J = 8.8 Hz, 2H), 7.10 (d, J = 8.8 Etazeta,IotaEta), 7.00 (d, J = 9.2 Hz, 2H), 6.86 (t, J = 7.6 Hz, 1H), 6.21 (s, 1H), 3.80 (br, 2H), 3.55 (br, 2H), 3.10 (m, 6H), 2.39 (s, 3H), 1.28 (t, J=7.2Hz, 3H); ESI-MS: calcd for (C26H27F3N60) 496, found 497 (MH+)., 115619-01-7

As the paragraph descriping shows that 115619-01-7 is playing an increasingly important role.

Reference£º
Patent; NANTBIOSCIENCE, INC.; TAO, Chunlin; POLAT,, Tulay; WEINGARTEN, Paul; NALLAN, Laxman; ARP, Forrest; WANG, Qinwei; HO, David; (129 pag.)WO2016/138527; (2016); A1;,
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21655-48-1, cis-2,6-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Palladium(II) acetate (0.225 g, 1.00 mmol) was added to ethyl 5-bromothiophene-2-carboxylate (2.351 g, 10 mmol), (2S,6R)-2,6-dimethylpiperazine (1.142 g, 10.00 mmol), rac-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (0.623 g, 1.00 mmol) and cesium carbonate (4.56 g, 14.00 mmol) in dioxane (100 ml) at 20¡ã C. under nitrogen. The resulting suspension was stirred at 105¡ã C. for 23 h. The mixture was evaporated to dryness to give a brown oil. This crude product was purified by ion exchange chromatography, using a SCX2 column. The crude material was dissolved in methanol and then applied to the column. The desired product was eluted from the column using 2M NH3 in methanol and pure fractions were evaporated to dryness to afford the crude product as a brown solid.This material was further purified by silica column chromatography, eluting with a gradient of 0 to 5percent MeOH in DCM. Pure fractions were evaporated to dryness to afford ethyl 5-((3S,5R)-3,5-dimethylpiperazin-1-yl)thiophene-2-carboxylate (1.600 g, 59.6percent) as a white solid. 1H NMR (399.9 MHz, CDCl3) delta 1.12-1.14 (6H, m), 1.33 (3H, t), 2.46-2.56 (2H, m), 2.98-3.07 (2H, m), 3.42-3.46 (2H, m), 4.28 (2H, q), 6.00 (1H, d), 7.55 (1H, d) MS: m/z 269 (MH+)

21655-48-1, The synthetic route of 21655-48-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; US2008/153812; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

196811-66-2, tert-Butyl 4-carbamothioylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 4-thiocarbamoyl-piperazine-1-carboxylic acid tert-butyl ester (0.2 g), 1,1,1-trifluoro-3-bromo-acetone (0.19 g) and triethylamine (0.33 g) in xylene (20 mL) were refluxed overnight. After cooling to room temperature, the solution was concentrated and purified by column chromatography to give 0.3 g of the desired intermediate as yellow oil., 196811-66-2

As the paragraph descriping shows that 196811-66-2 is playing an increasingly important role.

Reference£º
Patent; Kalypsys, Inc.; US2005/234046; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

25057-77-6, 1,2-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 65: tert-butyl (1 S)-1 -(4-((3,4-dimethylpiperazin-1- yl)methyl)phenyl)ethyl carbamateA solution of (S)-tert-butyl 1 -(4-formylphenyl)ethylcarbamate (84.1 mg, 0.337 mmol) [obtained from (S)-1-(4-bromophenyl)ethanamine following the procedure of Hashihayata, Takashi PCT Int. Appl., 2008081910, 10 Jul 2008] and 1 ,2- dimethylpiperazine (86.3 mg, 0.756 mmol, 2.24 equiv) in THF (1.5 mL) was stirred at room temperature for 65 min and treated with sodium triacetoxyborohydride (277.2 mg, 1 .308 mmol, 3.88 equiv). The resulting mixture was stirred at room temperature for 16 hours. The reaction mixture was quenched with saturated aqueous solution of NaHCO-3(15 mL) and extracted with EtOAc (5 x 15 mL). Combined organics were dried over Na2S04, filtered and concentrated. Silica gel column chromatography (MeOH/CH2Cl2 0 to 20%) provided tert-butyl (1 S)-1 -(4-((3,4-dimethylpiperazin-1-yl)methyl)phenyl)ethyl carbamate (90.7 mg) in 34.5% yield. 1 H NMR (400 MHz, CD3OD) delta 7.29 (s, 4 H), 4.68 (br s, 1 H), 3.54 – 3.47 (m, 2 H), 3.37 (s, 1 H), 2.84 – 2.74 (m, 3 H), 2.38 (td, J = 12, 2.5 Hz, 1 H), 2.31 (s, 3 H), 2.28 – 2.22 (m, 2 H), 1.94 – 1.89 (m, 1 H), 1.40 (br s, 9 H), 1.38 (d, J = 6.9 Hz, 3 H), 1 .06 (d, J = 6.3 Hz, 3 H); MS m/z 348.2 (M + H)

25057-77-6, As the paragraph descriping shows that 25057-77-6 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; CHO, Young Shin; LEVELL, Julian Roy; TOURE, Bakary-Barry; YANG, Fan; CAFERRO, Thomas; LEI, Huangshu; LENOIR, Francois; LIU, Gang; PALERMO, Mark G.; SHULTZ, Michael David; SMITH, Troy; COSTALES, Abran Q.; PFISTER, Keith Bruce; SENDZIK, Martin; SHAFER, Cynthia; SUTTON, James; ZHAO, Qian; WO2013/46136; (2013); A1;,
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Piperazines – an overview | ScienceDirect Topics

639068-43-2, tert-Butyl 3,5-dimethylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,639068-43-2

3,5-Dimethylpiperazine-1-carboxylic acid tert-butyl ester (1.676 g) and 2-chloropyrimidine (716 mg) were combined, melted in an oil bath at 120¡ãC, and stirred for 5 hr 30 min. Water (10 ml) was added and the mixture was stirred, extracted with ethyl acetate (30 ml), and washed with saturated brine. The extract was dried over anhydrous sodium sulfate, and the solvent was evaporated. The obtained residue was purified by column chromatography (Yamazen HI-FLASH.(TM). COLUMN size L, elution solvent: hexane/ethyl acetate) to give the title compound (333 mg). 1H-NMR (CDCl3)delta:1.25(6H,d,J=6.9 Hz), 1.51(9H,s), 2.97-3.08(2H,m), 3.95-4.16(2H,m), 4.65-4.82(2H,m), 6.51(1H,t,J=4.5 Hz), 8.34(2H,d,J=4.8 Hz). MS:237 (M++1 when tert-butyl group was cleaved).

639068-43-2 tert-Butyl 3,5-dimethylpiperazine-1-carboxylate 22219990, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Mitsubishi Tanabe Pharma Corporation; EP2154135; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

55121-99-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55121-99-8,(4-Aminophenyl)(4-methylpiperazin-1-yl)methanone,as a common compound, the synthetic route is as follows.

(11) methyl 3-(Z)-[1-{4-[(4-methyl-piperazin-1-yl)-carbonyl]-phenylamino}-1-phenyl-methylidene]-2-indolinone-6-carboxylate Prepared from 1-acetyl-3-(1-ethoxy-1-phenylmethylene)-6-methoxycarbonyl-2-indolinone and 4-(4-methyl-piperazin-1-yl-carbonyl)-aniline. Yield: 0.1 g (23% of theoretical), Melting point: 196-197 C.

As the paragraph descriping shows that 55121-99-8 is playing an increasingly important role.

Reference£º
Patent; Roth, Gerald Juergen; Heckel, Armin; Lehmann-Lintz, Thorsten; Kley, Joerg; Hilberg, Frank; Van Meel, Jacobus; US2003/92756; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics