Month: December 2020

20327-23-5, 1-Cyclopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

20327-23-5, In 100 mL round bottom flask, 1.84 g (10 mmol) of compound II was added, 1.26 g (10 mmol) of compound III-2 and 20 mL of dry THF were added and the resulting mixture was stirred under ice-cooling in water. After adding 2.48 g (12 mmol) of DCC, stirring was continued at room temperature overnight. TLC shows the completion of the reaction.The reaction mixture was poured into ice water, stirred, extracted with 50 mL of X3 in dichloromethane, the combined organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, and the solvent was evaporated on a rotary evaporator. The resulting residue was subjected to column chromatography purification, To give product 1-2 as a white solid.

The synthetic route of 20327-23-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Zhejiang Pharmaceutical College; GUO, ZHANG HUA; (6 pag.)CN104356060; (2016); B;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.118753-66-5,tert-Butyl 4-aminopiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

(ii) 4-({1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-indole-2-carbonyl}-amino)-piperazine-1-carboxylic acid tert-butyl ester To a solution of 1 g 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-indole-2-carboxylic acid and 1.3 ml NEM in 8 ml DCM, 914 mg TOTU were added and the mixture was stirred for 30 min at RT. Then 673 mg 4-Amino-piperazine-1-carboxylic acid tert-butyl ester were added and the reaction was stirred over night. After removal of the solvent under reduced pressure the residue was directly purified by chromatography on silica gel eluding with an ethyl acetate/heptane gradient. Yield: 1.1 g., 118753-66-5

The synthetic route of 118753-66-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Nazare, Marc; Essrich, Melanie; Will, David William; Matter, Hans; Ritter, Kurt; Wehner, Volkmar; US2003/199689; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.163765-44-4,(R)-1-Boc-3-Methylpiperazine,as a common compound, the synthetic route is as follows.

Example 97′ {3-[6-(6-Methoxy-pyridin-3-yl)-quinazolin-4-yl]-phenyl}-((R)-2-methyl-piperazin-1-yl)-methanone To a stirred solution of 3-[6-(6-methoxy-pyridin-3-yl)-quinazolin-4-yl]-benzoic acid (100 mg, 0.254 mmol) in 2 mL of DMF, was added HBTU (144 mg, 0.381 mmol) and DIPEA (0.177 mL, 1.016 mmol). The reaction mixture was stirred at rt for 30 min, (R)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester (76 mg, 0.381 mmol) was added and the resulting reaction mixture stirred for a further 2 h at rt. The reaction was quenched with H2O, and extracted with CH2Cl2. The organic layer was washed with brine, dried over MgSO4, filtered and evaporated under vacuum. The residue was dissolved in 3 ml of CH2Cl2 and TFA (1 ml) was added. The reaction mixture was stirred at ambient temperature for 2 h. After this period of time, the mixture was concentrated and purified by preparative reverse phase Gilson HPLC and subsequent neutralization of the combined fractions over PL-HCO3 MP gave the title compound (29 mg, 26% yield) as a white powder. 1H-NMR (400 MHz, DMSO-d6, 298 K): delta ppm 1.23 (d, 3H) 2.55-3.2 (m, 7H) 3.91 (s, 3H) 6.95 (d, 1H) 7.62 (d, 1H) 7.72 (t, 1H) 7.81 (s, 1H) 7.98 (d, 1H) 8.11 (d, 1H) 8.22 (d, 2H) 8.38 (d, 1H) 8.59 (s, 1H) 9.38 (s, 1H). MS: 440.1 [M+1]+, Rt(2′)=0.89 min.

163765-44-4, As the paragraph descriping shows that 163765-44-4 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; COOKE, Nigel Graham; FERNANDES GOMES DOS SANTOS, Paulo Antonio; FURET, Pascal; HEBACH, Christina; HOGENAUER, Klemens; HOLLINGWORTH, Gregory; KALIS, Christoph; LEWIS, Ian; SMITH, Alexander Baxter; SOLDERMANN, Nicolas; STAUFFER, Frederic; STRANG, Ross; STOWASSER, Frank; TUFFILLI, Nicola; VON MATT, Anette; WOLF, Romain; ZECRI, Frederic; US2015/342951; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

109-07-9, 2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1. 9-fluoro-3-methyl-10- (3-methyl-piperazine)-7-oxo-7H- pyrido [1, 2, 3-de]-1, 4-benzoxazine-6-carboxylic acid: To a solution of 9,10-difluoro-2, 3- dihydro-3-methyl-7-oxo-7H-pyrido [1, 2, 3-de]-1, 4-benzoxazine-6-carboxylic acid (1.4 g, 4.99 mmol) in pyridine (15 ml) was added 2-methyl piperazine (1.00 g, 9.99 mmol) and refluxed at 100C for 24 hours. The reaction mixture was cooled and the product crashed out of solution providing the pure desired product (1.0 g, 55% yield). ESI MS m/z : [M + H] + 362., 109-07-9

109-07-9 2-Methylpiperazine 66057, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; CUMBRE INC.; WO2005/70941; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.192130-34-0,tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

The mixture of 4-(4-chloro-1,6-naphthyridin-2-yl)-N,N-diethylbenzamide (278 mg, 0.82 mmol), tert-butyl 4-(2-aminoethyl)piperazine-1-carboxylate (281 mg, 1.23 mmol) and K2C03 (226 mg, 1.64 mmol) in DMF (1 mL) was heated at 100¡ãC for l8hrs. The reaction mixture was poured into water (20 mL), extracted with EA (10 mL x 3). The combined organic layers were washed by water (10 mL x 3) and brine (10 mL), dried over Na2SO4. Filtered and the filtrate was concentrated under the reduced pressure to give the residue which was purified prep-TLC to afford tert-butyl 4-(2-(2-(4- (diethylcarbamoyl)phenyl)- 1 ,6-naphthyndin-4-ylamino)ethyl)piperazine- 1 -carboxylate (90 mg, 20percent). LC-MS (ESI): 533.3(M + 1)., 192130-34-0

As the paragraph descriping shows that 192130-34-0 is playing an increasingly important role.

Reference£º
Patent; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; PINKERTON, Anthony B.; ARDECKY, Robert J.; ZOU, Jiwen; (256 pag.)WO2018/204176; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5625-67-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5625-67-2,Piperazin-2-one,as a common compound, the synthetic route is as follows.

A 2-L Erlenmeyer flask was charged with 2-piperazinone (36.5 g, 364 mmol, Sigma- Aldrich, St. Louis, MO), sodium carbonate (116 g, 1093 mmol), 600 mL of dioxane, and 150 mL of water. To this was slowly added benzyl chloroformate (62.1 g, 364 mmol, Sigma-Aldrich, St. Louis, MO) at room temperature over 20 min. After the addition was complete, the mixture was stirred for 2 h and then diluted with water and extracted with EtOAc (2 L). The combined organic extracts were dried (MgS04), filtered, and concentrated to give a white solid. To this solid was added 500 mL of DCM, triethylamine (128 mL, 911 mmol), DMAP (4.45 g, 36.4 mmol), and di-tert-butyl dicarbonate (119 g, 546 mmol, Sigma-Aldrich, St. Louis, MO). After 1 h at room temperature, the mixture was diluted with water and the organics were separated. The organics were dried (MgS04), filtered, and concentrated to give a brown oil. To this oil was added 100 mL of DCM followed by 1 L of hexane. The resulting white solid was collected by filtration to give 4-benzyl 1-tert-butyl 2-oxo-l,4- piperazinedicarboxylate (101 g).

The synthetic route of 5625-67-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AMGEN INC.; ASHTON, Kate; BARTBERGER, Michael David; BO, Yunxin; BRYAN, Marian C.; CROGHAN, Michael; FOTSCH, Christopher Harold; HALE, Clarence Henderson; KUNZ, Roxanne Kay; LIU, Longbin; NISHIMURA, Nobuko; NORMAN, Mark H.; PENNINGTON, Lewis Dale; POON, Steve Fong; STEC, Markian Myroslaw; ST. JEAN, David, Joseph, Jr.; TAMAYO, Nuria A.; TEGLEY, Christopher Michael; YANG, Kevin Chao; WO2012/27261; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.53788-49-1,tert-Butyl 4-methylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.,53788-49-1

Deprotection; A solution of 1:1 TFA, DCM with 0.5% water was prepared. This solution was added to the material isolated from the reduction, above (10 mL/g starting material). The reaction was stirred for 30 minutes then the solvent was removed with a rotoevaporator. Solvent evaporation was terminated when no more solvent was observed to be collecting on the condenser. TFA was added to the product residue (2 mL/g starting material) to form a free flowing solution. The TFA solution was transferred to a centrifuge tube and diethyl ether was added to precipitate the product salt. The solution was mixed using a vortex. The solution was then centrifuged and the supernatant decanted to collect the precipitate. The filtrate was then washed 1 time with ether by resuspending the product, vortexing, and re-centrifugation. Product was dried under low vacuum to remove residual ether.

As the paragraph descriping shows that 53788-49-1 is playing an increasingly important role.

Reference£º
Patent; Applera Corporation.; US2005/148774; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.132710-90-8,1-Boc-4-(3-hydroxypropyl)piperazine,as a common compound, the synthetic route is as follows.

e-1 – carboxylate0.61 ml (3.07 mmol) of diisopropyl diazene-l,2-dicarboxylate is added drop by d r o p a t 0 C under argon to 0.5 g (2.05 mmol) of tert-butyl 4-(3- hydroxypropyl)piperazine-l -carboxylate, 0.3 g (2.46 mmol) of 4-hydroxybenzaldehyde and 1 g (3.07 mmol) of supported triphenylphosphine (3 mmol/g of resin) diluted in 14.5 ml of anhydrous tetrahydrofuran. The reaction mixture is stirred at room temperature for 20 hours, and then the solid is filtered and rinsed with dichloromethane. The filtrate is concentrated and diluted in sodium hydroxide solution (1 M), the product is extracted several times with ethyl acetate, and then the organic phases are combined, dried on magnesium sulfate and concentrated. The residue is purified by silica gel chromatography (eluent: 4:6 cyclohexane/ethyl acetate to 100% ethyl acetate) to yield 0.58 g of tert-butyl 4-(3-(4-formylphenoxy)propyl)piperazine-l -carboxylate in the form of a colorless oil.LCMS (ESI, m/z): (M+l) 348.91H MR: 6H pm 400 MHz, DMSO: 9.87 (1H, s, CHO), 7.86 (2H, d, CHarom), 7.12 (2H, d, CHarom), 4.13 (2H, t, CH2), 3.28-3.31 (4H, m, 2CH2), 2.44 (2H, t, CH2), 2.31-2.34 (4H, m, 2CH2), 1.91 (2H, q, CH2), 1.40 (9H, s, 3CH3)., 132710-90-8

132710-90-8 1-Boc-4-(3-hydroxypropyl)piperazine 16217800, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; PIERRE FABRE MEDICAMENT; RABOT, Remi; BEDJEGUELAL, Karim; KALOUN, El Bachir; SCHMITT, Philippe; RAHIER, Nicolas; MAYER, Patrice; FOURNIER, Emmanuel; WO2012/140114; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4318-42-7,1-Isopropylpiperazine,as a common compound, the synthetic route is as follows.

Step B: (4-[1 -(3,4-Dichloro-phenoxy)-3-dimethylamino-propyH-phenyl)-(4-isopropyl-piperazin-1-yl)-methanone. To a solution of 3-dimethylamino-1-(4- iodo-phenyl)-propan-1-ol (289 mg, 0.640 mmol) in THF (4 ml.) was added DBU (293 mg, 1.93 mmol), Pd(OAc)2 (29 mg, 0.128 mmol), a solution of 1- isopropylpiperazine (247 mg, 1.93 mmol) in THF (2 ml_), and Mo(CO)6 (169 mg, 0.640 mmol). The mixture was heated in a microwave reactor for 15 min at 100 0C, cooled to rt, and filtered through a pad of diatomaceous earth. The filtrate was concentrated and the residue purified by acidic reverse phase HPLC to give the desired product (225 mg, 35percent) as an orange/brown oil. MS (ESI): mass calcd. for C25H33CI2N3O2, 477.19; m/z found, 478.8 [M+H]+. 1H NMR (MeOD): 7.54-7.49 (m, 4H), 7.28 (d, J = 8.9, 1 H), 7.07-7.06 (m, 1 H), 6.83(dd, J = 8.9, 2.9, 1 H), 5.49-5.46 (m, 1 H), 3.56-3.50 (m, 2H), 3.42-3.27 (m, 7H), 2.89 (s, 6H), 2.43-2.33 (m, 2H), 2.31-2.22 (m, 2H), 1.34 (d, J = 6.6, 6H).

4318-42-7, 4318-42-7 1-Isopropylpiperazine 78013, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; JANSSEN PHARMACEUTICA N.V.; WO2008/64036; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

20327-23-5, 1-Cyclopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

500mg of4-(4-(( 1 -(3-isopropyl- 1 ,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3- enecarboxyilc acid was put into a 100 ml flask under a nitrogen atmosphere, 20 ml of dichloromethane was added thereto, and the resulting mixture was then dissolved while stirring. 0.32 ml of triethylamine, 160 mg of 1-cyclopropylpiperazine, and 510 mg of HATU were added dropwise thereto, and the mixture was stirred at 20C for an hour. After the reaction was terminated, 20 ml of dichloromethane was additionally added thereto, and the resulting organic layer was washed with 20 ml of distilled water, dried with anhydrous magnesium sulfate, concentrated, and then isolated by silica column chromatography to obtain the title compound (Amount obtained: 430 mg /Yield: 69%).1H NMR (400, CDC13): 7.31 (2H, d), 6.82 (2H, d), 6.03 (1H, m), 4.18 (2H, d), 3.82(2H, d), 3.64 (2H, m), 3.53 (2H, m), 3.12 (2H, m), 2.89 (1H, m), 2.77 (1H, m), 2.66(4H, m), 2.50 (3H, m), 2.30 (1H, m), 2.00 (5H, m), 1.67 (1H, m), 1.45 (2H, m), 1.28(6H, d), 0.49 (4H, m), 20327-23-5

20327-23-5 1-Cyclopropylpiperazine 4742004, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; HYUNDAI PHARM CO., LTD.; YANG, Jin; KIM, Jin Woong; LEE, Han Kyu; KIM, Jae Hyun; SON, Chang Mo; LEE, Kyu Hwan; HWANG, Jeong Un; CHOI, Hyung Ho; KIM, Dae Hoon; RHEE, Jae Keol; (415 pag.)WO2017/78352; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics