Month: December 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1235865-77-6,2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4′-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid,as a common compound, the synthetic route is as follows.

General procedure: 2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-4-(4-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl)methyl)piperazin-1-yl)benzoic acid (5) was synthesized by the method reported. [Nat Med. 2013, 19(2): 202-8] To a solution of compound 5 (100 mg, 0.175 mmol) in anhydrous dichloromethane, compound 4g (68 mg, 0.175 mmol), EDCI (167 mg, 0.875 mmol) and DMAP (25.6 mg, 0.21 mmol) were added. Afterwards, the mixture solution was stirred for 24 h at room temperature. Completion of the reaction was confirmed by TCL. The reaction mixture was washed with HCl (1 M), NaHCO3 saturated solution and brine, concentrated and purified to afford 6g (160 mg, 85% yield) as a yellow solid.

1235865-77-6, The synthetic route of 1235865-77-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zhou, Ruolan; Fang, Shaoyu; Zhang, Minmin; Zhang, Qingsen; Hu, Jian; Wang, Mingping; Wang, Chongqing; Zhu, Ju; Shen, Aijun; Chen, Xin; Zheng, Canhui; Bioorganic and Medicinal Chemistry Letters; vol. 29; 3; (2019); p. 349 – 352;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.502649-29-8,1-Boc-3-Benzylpiperazine,as a common compound, the synthetic route is as follows.

To a flask was added tert- butyl 3-benzylpiperazine-1-carboxylate (CAS: 502649-29-8, Vendor: BePharm, 300 mg, 1.09 mmol), TEA (330 mg, 454 pL, 3.26 mmol) and DCM (2 mL). Then it was cooled with ice bath and Cbz-Cl (278 mg, 232 pL, 1.63 mmol) was added drop-wise. After being warmed to rt slowly and stirred for 2 hrs, the reaction mixture was diluted with 20 mL water and extracted with EA (15 mL) twice, the organic layer was dried over Na2S04 and concentrated to give a brown oil. After purification by flash column (EA/PE= 0 to 20%), the compound 39a (268 mg) was obtained as an oil. MS: calc’d 411 (MH+), measured 411 (MH+)., 502649-29-8

Big data shows that 502649-29-8 is playing an increasingly important role.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; LIU, Haixia; SHEN, Hong; ZHU, Wei; HU, Taishan; ZHANG, Zhisen; ZHANG, Zhiwei; DEY, Fabian; WANG, Xiaoqing; (89 pag.)WO2019/238629; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

76003-29-7, 1-Boc-3-Oxopiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[005961 To a stirring solution of 1 -bromo-4-(heptyloxy)benzene (447 mg. 1.65 nunol) in dioxane (5 niL) were added tert-butyl 3-oxopiperazine-1-carboxylate (330 mg, 1.65 mmol), copper I iodide (31.4 mg, 0.17 mmol), (1R,2R)-Nl .N2-dimethylcyclohexane- 1,2- diarnine (234 mg. 1.65 nmiol) and potassium carbonate (456 rng, 3.30 mmol). The reaction mixture was heated at 120C for 16 h. The reaction mixture was passed through a plug of celite, eluted with EA (50 mL). The organics were washed with ammonium chloride (25 niL), water (25 niL) and brine (25 mL) then dried over MgSO4 and concentrated to afford 602 mg (89%) of tert-butyl 4-(4-(heptyloxy)phenyl)-3- oxopiperazine-l-carboxylate. LCMS-ESI (m/z) calculated for C22H34N204: 390.5; found 319.0 [M+Hf. 1R= 2.90 mi (i1vlethod4).

76003-29-7, The synthetic route of 76003-29-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CELGENE INTERNATIONAL II SARL; BOEHM, Marcus, F.; MARTINBOROUGH, Esther; MOORJANI, Manisha; TAMIYA, Junko; HUANG, Liming; YEAGER, Adam, R.; BRAHMACHARY, Enugurthi; FOWLER, Thomas; NOVAK, Andrew; MEGHANI, Premji; KNAGGS, Michael; GLYNN, Daniel; MILLS, Mark; (851 pag.)WO2016/94729; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.

934-98-5, General procedure: General procedure: Hydroxylamine hydrochloride (1.58 mmol)and sodium hydroxide (2.65 mmol) were added to an ice-cooledsuspension of the proper ketone compound (0.53 mmol) in 10 mlof a mixture of ethanol/H2O (2:1). After stirring for 15 min at rt,the mixture was refluxed for 2 h. The ethanol was evaporatedand the alkaline aqueous solution was neutralized with 1N HCl.When possible, the obtained suspension was filtered and the aqueoussolution was extracted with CH2Cl2 and the organic layer wasdried with anhydrous Na2SO4 and evaporated to dryness. Thecrude residue was purified as indicated for each compound.

934-98-5 2-(4-Methylpiperazin-1-yl)ethanamine 70284, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Barteselli, Anna; Parapini, Silvia; Basilico, Nicoletta; Mommo, Danilo; Sparatore, Anna; Bioorganic and Medicinal Chemistry; vol. 22; 21; (2014); p. 5757 – 5765;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.113028-17-4,Ethyl 6-fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate,as a common compound, the synthetic route is as follows.

Ethyl-6-fluoro-1 -methyl-4-oxo-7-(1 -piperazinyl)-4H-(1 ,3)-thiazeto-[3,2-a]-quinoline-3- carboxylate (100 gms, 0.265 moles) was stirred in water (600 ml) at 25-30C. To this potassium hydroxide solution (50 gms of potassium hydroxide flakes is dissolved in 200 ml of water) was added and the reaction mass was heated to 80-85C. The contents were stirred for 1 hour and after completion of reaction, the reaction mass was cooled to 25-30C. The pH of the reaction mass was adjusted to 6.5-7.0 using 1:1 aqueous acetic acid solution. The contents were stirred at room temperature for 1 hour. The precipitated solid was filtered, washed with water (2 x 100 ml). The solid was slurried in methanol (300 ml) for 1 hour at 25-30C, filtered, washed with methanol (2 x 50 ml) and dried under vacuum at 70-75C to yield the title compound [90 gms, 97% yield, 96% HPLC purity].

113028-17-4, The synthetic route of 113028-17-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CIPLA LIMITED; PATHI, Srinivas Laxminarayan; RAO, Dharmaraj Ramachandra; KANKAN, Rajendra; CHINIMILLI, Venugopalarao; CURTIS, Philip Anthony; WO2012/1357; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

31166-44-6, 1-Cbz-Piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of benzyl piperazine-1 -carboxylate (500.00 mg, 2.27 mmol) in 1 ,4-Dioxane (30.00 mL) were added 37percent HCHO (77.32 mg, 2.27 mmol) and 1-ethoxyphosphonoyloxyethane (2.27 mmol). Thereaction mixture was stirred at r.t. for 30 mm and then heated at 90-100 00 for 1 h. The mixture was poured into water (100 mL) and extracted with EtOAc (100 mLx3). The combined organic phases were washed with brine (1 00 mL), dried over anhydrous Mg504 and concentrated. The residue was purified by flash column chromatography on silica gel (Petroleum Ether:EtOAc = 1:1) to afford 4.2 (700.00 mg, 1 .89 mmol, 83percent yield). MS (ESI) m/z = 371 [M¡ÂH]. 1H NMR (400 M, ODd3), oe 7.377.32 (m, 5H), 5.13 (s,2H), 4.21 4.1 1 (m, 4H), 3.55 (s, 4H), 2.82 (d, 2H, J = 116 Hz), 2.65 (m, 4H), 1.35 (m, 6H).

31166-44-6, As the paragraph descriping shows that 31166-44-6 is playing an increasingly important role.

Reference£º
Patent; UNITY BIOTECHNOLOGY, INC.; BACKES, Bradley; W. VON GELDERN, Thomas; CHEN, Bing; (121 pag.)WO2017/101851; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

106261-48-7, 4-((4-Methylpiperazin-1-yl)methyl)benzoic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Method E; To a flask was added 4-((4-methylpiperazin-1-yl)methyl)benzoic acid (3.2 g), dicyclohexylcarbodiimide (3.0 g), N-(5-amino-2-methylpyridin-3-yl)-4-(3-pyridyl)pyrimidin-2-amine (3.0 g) and CH2Cl2 (100 mL) and the reaction mixture was stirred at room temperature overnight. The reaction mixture was filtrated and the filtrate was washed with water (100 mL ¡Á 2), dried, filtrated, concentrated, and purified through column chromatography to give 4-[(4-methylpiperazin-1-yl)methyl]-N-{6-methyl-5-[(4-(pyrid-3-yl)pyrimid-2-yl)amino]pyrid-3-yl}benzamide (4.0 g).

106261-48-7, The synthetic route of 106261-48-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sun, Piaoyang; EP1840122; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5308-25-8,1-Ethylpiperazine,as a common compound, the synthetic route is as follows.

5308-25-8, 8.9 ml of ethylpiperazine are placed in 91.5 ml of toluene in a round-bottomed flask. A solution of 4.1 ml of ethyl bromoacetate in 11.6 ml of toluene is added dropwise. The mixture is refluxed at 110 C. for one hour, concentrated to a small volume and left in a refrigerator for 3 hours. A white precipitate forms, which is filtered off and washed with dichloromethane. The filtration liquors are evaporated; 7 g of expected product are obtained.

5308-25-8 1-Ethylpiperazine 79196, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; SANOFI-AVENTIS; US2010/210662; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109-01-3,1-Methylpiperazine,as a common compound, the synthetic route is as follows.

To a 500 mL one-necked flask was added p-nitrobenzyl bromide (10 g, 46.3 mmol)And 100 mL of dichloromethane,4.7 g (47.0 mmol) of N-methylpiperazine was slowly added dropwise under ice-cooling (0-5 C)And triethylamine (7.1 g, 70.3 mmol)Of dichloromethane 20mL mixture, plus heat heating reflux 1h,TLC detected the disappearance of the starting material (ethyl acetate: petroleum ether = 1: 2).150 mL of chloroform and 100 mL of saturated sodium bicarbonate solution were added to the reaction solution,Stir for 30 min at room temperature. The reaction solution was extracted with chloroform (100 mL x 3)The organic layers were combined and washed once with water and saturated sodium chloride (100 mL x 1).Dried over anhydrous magnesium sulfate, filtered,The solvent was evaporated under reduced pressure to give 8.5 g of a pale yellow solid in a yield of 78.1%Products without further purification, directly into the next step.

109-01-3, The synthetic route of 109-01-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; China Pharmaceutical University; Lu Shuai; Wang Yue; Zhi Yanle; Yao Chao; Lu Tao; Li Baoquan; Chen Puzhou; Bao Jiyin; (27 pag.)CN107245073; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.70261-82-4,4-(4-Methylpiperazin-1-ylmethyl)phenylamine,as a common compound, the synthetic route is as follows.

70261-82-4, To Example 55D (75 mg, 0.198 mmol) and m-chloroperoxybenzoic acid (53.3 mg, 0.238 mmol) was added 2 mL dichlormethane. The reaction was stirred for 15 minutes when 4-((4-methylpiperazin-1-yl)methyl)aniline (48.9 mg, 0.238 mmol) followed by trifluoroacetic acid (0.031 ml, 0.397 mmol). The mixture was stirred at 50 C. for 1 hour, and at room temperature overnight. The mixture was diluted with ethyl acetate, washed with saturated aqueous NaHCO3, water, and brine, dried over MgSO4, filtered and concentrated. The crude material was dissolved in methanol, and treated with 2N HCl in diethyl ether for 1 hour. The mixture was diluted with diethyl ether and filtered. The solid was triturated with 1:1 DMSO/methanol solution, diluted with ethyl acetate, filtered, and dried over high-vacuum to provide the title compound. 1H NMR (501 MHz, DMSO-d6) delta 2.53 (s, 2H) 2.78 (s, 2H) 3.15 (s, 3H) 3.19-3.50 (m, 4H) 3.91 (s, 2H) 7.09 (d, J=1.18 Hz, 1H) 7.47 (d, J=7.58 Hz, 2H) 7.55-7.64 (m, 1H) 7.66-7.74 (m, 2H) 7.80 (d, J=1.66 Hz, 1H) 7.86 (d, J=8.06 Hz, 2H) 9.16 (s, 1H). MS (ESI+) m/z 534.9 (M+H)+.

70261-82-4 4-(4-Methylpiperazin-1-ylmethyl)phenylamine 3153996, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; ABBOTT LABORATORIES; US2012/220572; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics