Month: December 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13754-38-6,1-Benzoylpiperazine,as a common compound, the synthetic route is as follows.

General procedure: A mixture of 12 (0.3 mmol) and PyBOP (0.45 mmol) in THF (20 mL) was stirred for 10 min. Afterwards, the corresponding amine (0.34 mmol) and DIPEA (0.76 mmol) were given to the mixture and stirred overnight at RT. The crude mixture was evaporated, the product was dissolved in EtOAc, washed with Na2CO3 solution, and dried over Na2SO4. After evaporation, the product was purified by column chromatography (eluent: CHCl3/MeOH)., 13754-38-6

The synthetic route of 13754-38-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Sauer; Skinner-Adams; Bouchut; Chua; Pierrot; Erdmann; Robaa; Schmidt; Khalife; Andrews; Sippl; European Journal of Medicinal Chemistry; vol. 127; (2017); p. 22 – 40;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13484-40-7,1-(2-Methoxyethyl)piperazine,as a common compound, the synthetic route is as follows.

13484-40-7, Preparation of 2-Chloro-6-[4-(2-methoxy-ethyI)-piperazin-l-yl]-pyrimidine-4- carboxylic acid methyl ester:; To a solution of 2,6-dichloro-pyrimidine-4-carboxylic acid methyl ester (580 mg, 2.8 mmol) in DCM (6 mL) at 0 C was added triethylamine (0.39 mL, 2.8 mmol), followed by a solution of l-(2-methoxyethyl)piperazine (406 mg, 2.8 mmol) in DCM (6 mL). The resulting solution was stirred at 0 C for 30 min. The reaction mixture was diluted with water and extracted with DCM (3×80 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated to afford 870 mg (99%) of the title compound as a pale yellow solid.

13484-40-7 1-(2-Methoxyethyl)piperazine 2734638, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; SIRTRIS PHARMACEUTICALS, INC.; WO2009/61453; (2009); A1;,
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Piperazines – an overview | ScienceDirect Topics

7365-45-9,7365-45-9, 2-(4-(2-Hydroxyethyl)piperazin-1-yl)ethanesulfonic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: In a typical procedure, 10 mL zinc acetate solution (200 mM) was mixed with 20 mL HEPES solution (200 mM pH 7.4). A microwave and ultrasonic wave combined reactor (XH-300A, Beijing Xianghu Technology Co., Ltd.) provided continuous and homogeneous ultrasonic wave and microwave irradiation for the mixed solutions. Firstly, the mixture was continuously sonicated for 5 min by ultrasonic processor with a power of 1000 W. Then the mixed solution was heated to 110 C within 3 min and kept at this temperature for 17 min under microwave heating combined with discontinuous ultrasonic irradiation (1 s sonication and 2 s interruption) with a power of 500 W. After cooling down to room temperature naturally, the product was collected by centrifugation and washed with deionized water and absolute alcohol for 5 times, then dried in a desiccator for further characterization (S1). Other ZnO samples (S2-S15) were also prepared under identical conditions by varying Zn/HEPES moral ratio, pH value of HEPES solution and Zn precursor. The detailed procedure is same as described above and all the experimental parameters are listed in Table 1.

7365-45-9 2-(4-(2-Hydroxyethyl)piperazin-1-yl)ethanesulfonic acid 23831, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Li, Qin; Li, Hui; Wang, Runming; Li, Guangfang; Yang, Hao; Chen, Rong; Journal of Alloys and Compounds; vol. 567; (2013); p. 1 – 9;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.694499-26-8,4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline,as a common compound, the synthetic route is as follows.

694499-26-8, To a stirred solution of methyl XXX (0.150 g, 0.46 mmol) and V (0.191 g, 0.70 mmol) in methanol(5 mL) was added acetic acid in catalytic amount, reaction mass was allowed to stir at RT for 30 min thenNaCNBH4 was added to the reaction mass and allowed to stirred at RT for overnight. After completion ofreaction RM was evaporated under vacuum to obtain crude which was diluted with water and product wasextracted with ethyl acetate (30 mL X 3) and brine washing was given to organic layer and dried overanhydrous Na2SO4 and evaporated under vacuum and purified though reverse phase HPLC to obtaincompound 12 (0.06 g, 22%).LCMS: 579 [M+1]+1HNMR (400 MHz, DMSO) delta 10.0 (s, 1H), 8. 2 (s, 1H), 7.9 (t, 3H), 7.5 (m, 2H), 7.4 (m, 1H), 7.3 (m, 2H),7.2 (d, 2H), 7.1 (d, 2H), 4.2 (s, 1H), 3.5 (s, 3H), 2.5 (s, 1H), 2.4 (m, 6H), 2.3 (m, 4H), 2.2 (s, 3H).

The synthetic route of 694499-26-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ramachandran, Sreekanth A.; Jadhavar, Pradeep S.; Miglani, Sandeep K.; Singh, Manvendra P.; Kalane, Deepak P.; Agarwal, Anil K.; Sathe, Balaji D.; Mukherjee, Kakoli; Gupta, Ashu; Haldar, Srijan; Raja, Mohd; Singh, Siddhartha; Pham, Son M.; Chakravarty, Sarvajit; Quinn, Kevin; Belmar, Sebastian; Alfaro, Ivan E.; Higgs, Christopher; Bernales, Sebastian; Herrera, Francisco J.; Rai, Roopa; Bioorganic and Medicinal Chemistry Letters; vol. 27; 10; (2017); p. 2153 – 2160;,
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Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.122833-04-9,2-Methoxy-4-(4-methylpiperazin-1-yl)aniline,as a common compound, the synthetic route is as follows.

A solution of 2-chloro-9-cyclopentyl-7-ethyl-purin-8-one (Method 5) (0.1 g), 2-methoxy- 4-(4-methylpiperazin-l-yl)aniline (Compound 46-3, page 138 in WO 04/080980) (0.16 g) and 4-toluenesulphonic acid (0.13 g) in 2-propanol (2 mL) was heated at 1900C for Ih by microwave. After cooling the mixture was concentrated in vacuo and purified by FCC using 0-5% of (10:1 MeOetaxonc. aq. NH3) in DCM to afford the title compound (0.05 g, 31%) as a pale yellow foam; 1H NMR: (CDCl3) 1.34 (3H, t), 1.68 (2H, m), 2.33 (2H, m), 2.36 (3H, s), 2.60 (4H, m), 3.17 (4H, m), 3.87 (2H, q), 3.89 (3H, s), 4.81 (IH, tt), 6.55 (IH, dd), 6.57 (IH, s), 7.30 (IH, s), 7.86 (IH, s), 8.25 (IH, d); m/z: MH+ 453; EAA: 0.220; EAA2: 0.0538.

122833-04-9, The synthetic route of 122833-04-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/24824; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.169447-86-3,(S)-tert-Butyl 2-benzylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of the free carboxylic acid (1 equiv.) in dry dichloromethane (0.05 M solution) (S)-lambdaM -Boc-2-benzylpiperazine (1.05 equiv.), EDCI (1.1 equiv.), HOBt (1.1 equiv.) and DIPEA (2 equiv.) were added at room temperature. The reaction was stirred overnight, the solvent evaporated under reduced pressure and the crude material purified by flash chromatography.; (S)-fert-butyl-2-benzyl-4-[5-/so-butyl-6-(3-/so-butyl-1W-pyrazol-5- yl)pyridazine-3-carbonyl]piperazine-1-carboxylate 12b: Rf = 0.21 (CH2CI2/Me0H = 98:2)., 169447-86-3

169447-86-3 (S)-tert-Butyl 2-benzylpiperazine-1-carboxylate 17750441, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; THE SCRIPPS RESEARCH INSTITUTE; WO2009/25751; (2009); A1;,
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Piperazines – an overview | ScienceDirect Topics

314741-40-7, (S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Diisopropylethylamine (44.0 mL, 252 mmoi)was added to a stirred, room temperature mixture of ?72 wt% 3-(2-Bromo-acetyi)-6-fiuoro-2-methyi-benzonitriie (69 g, 194 mmoi) and (S)-4-N-Boc-2-hydroxymethyi-piperazine (42.0 g, 194mmoi) in THF (1000 mL) and the mixture was stirred at room temperature for 18h. The reactionwas diluted with 1 L EtOAc, washed 2x with 500 m 10% w/w NaHCO3 aqueous solution, dried oyer MgSO4, filtered and concentrated. The residue was purified by coiumn chromatography on silica gel (40-80% EtOAc/Hexanes, linear gradient), to giye the titie compound.

314741-40-7, As the paragraph descriping shows that 314741-40-7 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; PASTERNAK, Alexander; DE JESUS, Reynalda, Keh; DING, Fa-xiang; DONG, Shuzhi; FRIE, Jessica; GU, Xin; JIANG, Jinlong; SHAHRIPOUR, Aurash; PIO, Barbara; TANG, Haifeng; WALSH, Shawn; WO2014/126944; (2014); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161357-89-7,1-(Methylsulfonyl)piperazine hydrochloride,as a common compound, the synthetic route is as follows.

Example 5: . 2-(lH-IndoI-4-yI)-6-(4-inethanesuIfonvI-piperazin-l-vImethvI)-4- morphoIm-4-yI-thienor2,3-d1pyrimidine; 2-Chloro-6-(4-methyl-piperazm-l-ylmethyl)-4-morpholin-4-yl-thieno[2,3- dlpyrimidine ‘ 2-Chloro-4-morpholin-4-yl-thieno[2,3-d]pyrimidine-6-carbaldehyde (400 mg) and 1-methanesulfonyl-piperazine hydrochloride (1.3eq.) were stirred together in dry 1,2-dichloroethane (20 mL). After 4h sodium triacetoxyborohydride (2.3 eq.) was added and the mixture stirred overnight. The mixture was diluted with Na2CO3 solution then extracted with ethyl acetate. Combined extracts were dried (Na2SO4), filtered and concentrated. Trituration gave product (60%)., 161357-89-7

The synthetic route of 161357-89-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PIRAMED LIMITED; WO2007/122410; (2007); A1;,
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Piperazines – an overview | ScienceDirect Topics

791846-40-7, tert-Butyl 4-(4-bromo-2-cyanophenyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,791846-40-7

To a solution of 1-16 (2.5 g, 6.83 mmcl) in DMSO (6 mL) were added aqueous 30% H202 (0.15 ml, 8.88 mmcl) and K2003 at 0CC, and the reaction mixture was stirred at room temperature for 16 hours. After completion of the reaction, the reactionmixture was poured into ice cold water (100 ml) and extracted with diethyl ether (100 mL x 3) . The organic layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude product so obtained was purified by silica gel column chromatography (60-120 mesh) using 30% EtOAc in hexanesas eluent to give the desired product 1-17 (1.3 g, 50%) as a white solid; LOMS: m/z 384.0 [M+1]

As the paragraph descriping shows that 791846-40-7 is playing an increasingly important role.

Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; KOUL, Summon; KURHADE, Suresh; NAIK, Keshav; SALUNKHE, Videsh; KULKARNI, Rakesh; PARDESHI, Vishwajeet; BHUNIYA, Debnath; KULKARNI, Bheemashankar; MOOKHTIAR, Kasim Abbaas; (274 pag.)WO2017/38909; (2017); A1;,
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Piperazines – an overview | ScienceDirect Topics

75336-86-6,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.75336-86-6,(R)-2-Methylpiperazine,as a common compound, the synthetic route is as follows.

Solid K2CO3 (10 g, 72.4 mmol, 1.8 eq) is added to a solution of (R)-2-methyl-piperazine (4.00 g, 40 mmol, 1 eq) and 3,6-dichloro-4,5-dimethyl-pyridazine (8 g, 45.2 mml, 1.1 eq) in DMF (50 mL), and the resulting solution is stirred at 60¡ã C. for 48 h. The reaction mixture is concentrated to 1/2 volume under reduced pressure and the minimum water (ca. 15 mL) required to dissolve the solid salts is added, followed by the addition of dichloromethane (100 mL). The organic layer is separated, dried over sodium sulfate and concentrated under reduced pressure, then purified by silica gel column chromatography (2percent-20percent MeOH/CH2Cl2) to yield the desired compound as a white solid (4.7 g, 49percent).1H NMR (400 MHz, CDCl3) delta=3.08-3.21 (m, 2H), 2.73-2.92 (m, 4H,) 2.47 (dd, J=12.4 Hz, 10.2 Hz, 1H), 2.13 (s, 3H), 2.07 (s, 3H), 0.93 (d, J=6.3 Hz, 3H).HR MS (m/z, MH+): meas. 241.1218.

75336-86-6 (R)-2-Methylpiperazine 7330434, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Novartis AG; US2010/41663; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics