129799-08-2, 1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
The compound (S) -5- (1 – ((tert-butoxycarbonyl) amino) ethyl) -2- (3- (cyclopropylmethoxy) -4-(difluoromethoxy) phenyl ) -oxazole-4-carboxylic Acid (0.25g, 0.53mmol), the compound 1,3-piperazinecarboxylate hydrochloride (150mg, 0.64mmol), 1- ethyl-3- (3-dimethylamine propyl Yl) carbodiimidehydrochloride (153mg, 0.80mmol) and N- hydroxy-7-aza-benzotriazole (181mg, 1.33mmol) was dissolved indichloromethane Dioxane (20 mL), and under conditions of 0 C to this solution was added dropwise N, Ndiisopropylethylamine(0.37mL, 2.13mmol), stirred at room temperature 17H, The solvent was removed, theconcentrate was subjected to column chromatography (eluent: Petroleumether / EtOAc (v / v) = 2/1), to give260mg yellow viscous Material, yield: 74%., 129799-08-2
129799-08-2 1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate 2756819, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd; Zhang, Ying jun; Liu, Bing; Yu, Tian Zhu; Zhang, Xiang Yu; (348 pag.)CN105399698; (2016); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics