With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.122833-04-9,2-Methoxy-4-(4-methylpiperazin-1-yl)aniline,as a common compound, the synthetic route is as follows.
[00436] 2,5-Dichloro-N-(3-nitrobenzyl)pyrimidin-4-amine (150 mg, 0.5 mmol), 2- methoxy-4-(4-methylpiperazin-l-yl)aniline (166 mg, 0.75 mmol), and trifluoroacetic acid (57 mu, 0.75 mmol) was combined in sec-butanol (5 mL) and stirred overnight at 100 C. The mixture was then concentrated and purified by column chromatography (1087) (dichloromethane: methanol = 10: 1) to yield 184 mg (76%) of the title product as a pale- yellow solid. MS (ESI) m/z 484 (M+H)+.
122833-04-9, 122833-04-9 2-Methoxy-4-(4-methylpiperazin-1-yl)aniline 20136253, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; DANA-FARBER CANCER INSTITUTE, INC.; GRAY, Nathanael; TAN, Li; (219 pag.)WO2015/164614; (2015); A1;,
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