13484-40-7, 1-(2-Methoxyethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Compound 27 (prepared according to B 15) (0.133 g; 0.0002 mol) was dissolved in DMF (2 ml). PS-CDI, 1.9 mmol/g (0.320 g; 0.0006 mol) was added and HOBT (0.041 g; 0.003 mol) in DMF (2 ml) was added. The reaction mixture was shaken for 1 hour at room temperature. l-(2-Methoxyethyl)piperazine (0.0002 mol) in DMF (2 ml) was added. The reaction mixture was shaken overnight. MP-carbonate, 1 mmol/g (0.5 g) and polymer-bound isocyanate (0.111 g; 0.0002 mol) were added. The reaction mixture was shaken overnight. The reaction mixture was filtered, CH2Cl2 (3 ml) was added, and the mixture was shaken for 2 hours and filtered again. The filtrate was evaporated with the Genevac. The product was purified by reversed-phase high-performance liquid chromatography (Shandon Hyperprep C 18 BDS (Base Deactivated Silica) 8 mum, 250 g, LD. 5 cm). A gradient with 3 mobile phases was applied. Phase A: a 0.25 % NH4HCO3 solution in water; phase B : CH3OH; phase C: CH3CN). The desired fractions were collected and the solvent was evaporated. Yield: 22 mg of compound 275.
13484-40-7, 13484-40-7 1-(2-Methoxyethyl)piperazine 2734638, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; JANSSEN PHARMACEUTICA N.V.; WO2008/148868; (2008); A1;,
Piperazine – Wikipedia
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