With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4318-42-7,1-Isopropylpiperazine,as a common compound, the synthetic route is as follows.
Step B: (4-[1 -(3,4-Dichloro-phenoxy)-3-dimethylamino-propyH-phenyl)-(4-isopropyl-piperazin-1-yl)-methanone. To a solution of 3-dimethylamino-1-(4- iodo-phenyl)-propan-1-ol (289 mg, 0.640 mmol) in THF (4 ml.) was added DBU (293 mg, 1.93 mmol), Pd(OAc)2 (29 mg, 0.128 mmol), a solution of 1- isopropylpiperazine (247 mg, 1.93 mmol) in THF (2 ml_), and Mo(CO)6 (169 mg, 0.640 mmol). The mixture was heated in a microwave reactor for 15 min at 100 0C, cooled to rt, and filtered through a pad of diatomaceous earth. The filtrate was concentrated and the residue purified by acidic reverse phase HPLC to give the desired product (225 mg, 35percent) as an orange/brown oil. MS (ESI): mass calcd. for C25H33CI2N3O2, 477.19; m/z found, 478.8 [M+H]+. 1H NMR (MeOD): 7.54-7.49 (m, 4H), 7.28 (d, J = 8.9, 1 H), 7.07-7.06 (m, 1 H), 6.83(dd, J = 8.9, 2.9, 1 H), 5.49-5.46 (m, 1 H), 3.56-3.50 (m, 2H), 3.42-3.27 (m, 7H), 2.89 (s, 6H), 2.43-2.33 (m, 2H), 2.31-2.22 (m, 2H), 1.34 (d, J = 6.6, 6H).
4318-42-7, 4318-42-7 1-Isopropylpiperazine 78013, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; JANSSEN PHARMACEUTICA N.V.; WO2008/64036; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics