30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: Amine 15 (hydrochloride) (4.3 mmol) was dissolved in CH2Cl2 (5 ml), and the solution was cooled with an ice bath. A solution of ethyl chloroglyoxylate (4.7 mmol) in CH2Cl2 (2 ml) was added dropwise, and the mixture was stirred at 0C for 0.5-1 hour. The reaction solution was diluted with ethyl acetate. The organic layer was washed with an aqueous saturated sodium chloride solution and dried with anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain crude product. This crude product was dissolved in ethanol (13 ml), 2 mol/L sodium hydroxide (6.5 ml 13 mmol) was added, and the mixture was stirred at room temperature for 1.5 hour. The solvent was distilled off under reduced pressure, and 2 mol/L hydrochloric acid was added to the residue to acidic, and the precipitated crystal was collected by filtration. The crystal was washed with water and dried to obtain carboxylic acid 16 (yield 77-99%). To carboxylic acid 16 (1.0 mmol) were added DMF (10 ml), aniline (1.2 mmol), HOBt (1.2 mmol), triethylamine (1.2 mmol), DMAP (0.05 mmol) and WSCD¡¤HCl (1.2 mmol). The mixture was stirred at room temperature for overnight. An aqueous saturated sodium bicarbonate solution was added, and the aqueous layer was extracted with EtOAc. The organic layer was washed with brine, dried over MgSO4, and concentrated under reduced pressure. The residue was purified by amino silica gel column chromatography (CHCl3/MeOH, gradient: 0-10% MeOH) to afford oxamide 6a-v (yield 46-91%).
30459-17-7, 30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.
Reference£º
Article; Anan, Kosuke; Masui, Moriyasu; Tazawa, Aya; Tomida, Minoru; Haga, Yoshihiro; Kume, Masaharu; Yamamoto, Shoichi; Shinohara, Shunji; Tsuji, Hiroki; Shimada, Shinji; Yagi, Shigenori; Hasebe, Nobuyoshi; Kai, Hiroyuki; Bioorganic and Medicinal Chemistry Letters; vol. 29; 9; (2019); p. 1143 – 1147;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics