694499-26-8, 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
694499-26-8, To a solution of 3-(4-bromophenyl)propionic acid (42 mg, 0.18 mmol) in anhydrous N,N-dimethylformamide (2 mL) was treated HATU (139 mg, 0.36 mmol) andthe mixture was stirred at room temperature for 30 minutes. A solution of 4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)-aniline (50 mg, 0.18 mmol) and triethylamine (37 mg, 0.36 mmol) in anhydrous N,N-dimethylformamide (1.0 mL) was added. The reaction mixture was stirred at room temperature for 2 hours and partitioned between H20 (50 mL) and ethyl acetate (50 mL). The aqueous layer was extracted withethyl acetate (50 mL x 2). The combined organic extracts were washed with brine (100 mL), dried over sodium sulfate and concentrated in vacuum. The residue was purified by flash chromatography (Redisep silica gel, 9:1 dichloromethane/methanol) to afford 3 -(4- bromophenyl)-N- {4- [(4-methylpiperazin- 1 -yl)methyl] -3 -(trifluoromethyl)phenyl } -propanamide. ESI MS: m/z 486.05.
The synthetic route of 694499-26-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (A*STAR); CHERIAN, Joseph; DURAISWAMY, Athisayamani Jeyaraj; NACRO, Kassoum; WO2014/88519; (2014); A1;,
Piperazine – Wikipedia
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