With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.278788-66-2,(R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
To the solution of tert-butyl (3R)-3-(hydroxymethyl)piperazine-l-carboxylate (1044 mg, 4.83 mmoi) in N,N-Diisopropylethylamine (2.57 mL, 14.48 mmoi) and DMF (7 niL) was added (E)- 2-cyano-4,4-dimethyl-pent-2-enoic acid (1109.1 mg, 7.24 mmoi) followed by HATU (486.6 mg, 5.79 mmoi). The mixture was stirred at rt for 1 h. The mixture was diluted with DCM and water and partitioned. The organic layer was dried with MgSOa and concentrated. The cmde mixture was purified by column chromatography to obtain tert-butyl (3R)-4-[(E)-2-cyano-4,4-dimethyl-pent-2-enoyl]-3- (hydroxymethyl)piperazine-l-carboxylate (1340 mg) as an oil., 278788-66-2
The synthetic route of 278788-66-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; PRINCIPIA BIOPHARMA INC.; LOU, Yan; OWENS, Timothy, Duncan; BRAMELD, Kenneth, Albert; GOLDSTEIN, David, Michael; (230 pag.)WO2018/136401; (2018); A1;,
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