262368-30-9, N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of methyl (Z)-3-(chloro(4-methoxyphenyl)methylene)-2-oxoindoline-5-carboxylate (100 mg, 0.29 mmol), N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide (88 mg, 0.34 mmol) and TEA (0.08 mL, 0.59 mmol) in EtOH (1.0 mL) was stirred under refluxed for overnight. The reaction solvent was evaporated under reduced pressure, and the residue was purified by column chromatography with dichloromethane/ethanol (50/1, v/v) to obtain the final compound 96 as a yellow solid (164 mg, 99% yield): 1H NMR (500 MHz, DMSO-d6) _ 11.91 (s, 1H), 11.12 (s, 1H), 7.59 (dd, J = 8.2, 1.7 Hz, 1H), 7.43 (d, J = 8.6 Hz, 2H), 7.15 (d, J = 8.8 Hz, 3H), 6.94 (d, J = 8.2 Hz, 1H), 6.90 (d, J = 8.4 Hz, 2H), 6.65 (d, J = 1.5 Hz, 1H), 3.87 (s, 3H), 3.65 (s, 3H), 3.07 (bs, 3H), 2.87 (bs, 2H), 2.65 (bs.4H); 13C NMR (125 MHz, DMSO-d6) _ 170.4, 166.4, 160.7, 156.8, 140.4, 139.1, 130.2, 127.8, 125.4, 124.15, 124.09, 123.4, 121.2, 119.6, 115.0, 108.8, 97.8, 57.7, 55.5, 52.6, 51.5, 49.1; HRMS (ESI-TOF) m/z calcd for C32H35N5O5 [M + Na+] 592.2530, found 592.2531.
262368-30-9, As the paragraph descriping shows that 262368-30-9 is playing an increasingly important role.
Reference£º
Patent; BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM; DALBY, Kevin N.; EDUPUGANTI, Ramakrishna; TALIAFERRO, Juliana; LEE, Juhyeon; (0 pag.)WO2018/160967; (2018); A1;,
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