With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20327-23-5,1-Cyclopropylpiperazine,as a common compound, the synthetic route is as follows.
Step 4: A mixture of the chloropyrimidine (200 mg, 0.38 mmol), the piperazine (238 mg, 1.88 mmol) and N,N-diisopropylethylamine (0.26 mL, 1.51 mmol) in DMSO (1.5 mL) was heated in a sealed tube at 1 10 C for 2 h. The reaction was cooled to room temperature and diluted with water. The layer was then extracted with EtOAc (x2). The combined organic layers were washed with water and brine, dried over MgSC>4, filtered and concentrated to leave a residue which was used purified by column chromatography (Si02; elution with 2: 1 hexane:EtOAc) to yield the desired adduct. LCMS 621 [M+H]+.
20327-23-5, 20327-23-5 1-Cyclopropylpiperazine 4742004, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; MILLER, Michael; BASU, Kallol; DEMONG, Duane; SCOTT, Jack; LI, Wei; HARRIS, Joel; STAMFORD, Andrew; POIRIER, Marc; TEMPEST, Paul; WO2014/134772; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics