314741-40-7, (S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
tert-butyl (3S)-3-(hydroxymethyl)piperazine-1-carboxylate (2.5 g, 11.56 mmol), 2-fluoro-5-nitro-benzonitrile (1.92 g, 11.6 mmol) and DiPEA (2.47 ml, 13.9 mmol) were dissolved in 1,4-dioxane (25 ml). The reaction was heated to 80 C. for 24 hours then increased to 90 C. for a further 18 hours. The reaction was concentrated in vacuo. The residue obtained was purified via flash column chromatography using gradients of 0 to 100% EtOAc in heptane, followed by 0 to 100% MeOH in EtOAc. The fractions containing product were combined and concentrated in vacuo to afford the title compound as a yellow gel (4.07 g, 67%). LCMS Method 3-Tr=0.61 min (ES+) (M+H+) 363.2
314741-40-7, As the paragraph descriping shows that 314741-40-7 is playing an increasingly important role.
Reference£º
Patent; Navitor Pharmaceuticals, Inc.; O’Neill, David John; Saiah, Eddine; Kang, Seong Woo Anthony; Brearley, Andrew; Bentley, Jonathan; (519 pag.)US2018/127370; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics