314741-40-7, (S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Diisopropylethylamine (44.0 mL, 252 mmoi)was added to a stirred, room temperature mixture of ?72 wt% 3-(2-Bromo-acetyi)-6-fiuoro-2-methyi-benzonitriie (69 g, 194 mmoi) and (S)-4-N-Boc-2-hydroxymethyi-piperazine (42.0 g, 194mmoi) in THF (1000 mL) and the mixture was stirred at room temperature for 18h. The reactionwas diluted with 1 L EtOAc, washed 2x with 500 m 10% w/w NaHCO3 aqueous solution, dried oyer MgSO4, filtered and concentrated. The residue was purified by coiumn chromatography on silica gel (40-80% EtOAc/Hexanes, linear gradient), to giye the titie compound.
314741-40-7, As the paragraph descriping shows that 314741-40-7 is playing an increasingly important role.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; PASTERNAK, Alexander; DE JESUS, Reynalda, Keh; DING, Fa-xiang; DONG, Shuzhi; FRIE, Jessica; GU, Xin; JIANG, Jinlong; SHAHRIPOUR, Aurash; PIO, Barbara; TANG, Haifeng; WALSH, Shawn; WO2014/126944; (2014); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics