With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13754-38-6,1-Benzoylpiperazine,as a common compound, the synthetic route is as follows.
General procedure: A mixture of 12 (0.3 mmol) and PyBOP (0.45 mmol) in THF (20 mL) was stirred for 10 min. Afterwards, the corresponding amine (0.34 mmol) and DIPEA (0.76 mmol) were given to the mixture and stirred overnight at RT. The crude mixture was evaporated, the product was dissolved in EtOAc, washed with Na2CO3 solution, and dried over Na2SO4. After evaporation, the product was purified by column chromatography (eluent: CHCl3/MeOH)., 13754-38-6
The synthetic route of 13754-38-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Sauer; Skinner-Adams; Bouchut; Chua; Pierrot; Erdmann; Robaa; Schmidt; Khalife; Andrews; Sippl; European Journal of Medicinal Chemistry; vol. 127; (2017); p. 22 – 40;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics