With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3022-15-9,Piperazine-2-carboxylic acid dihydrochloride,as a common compound, the synthetic route is as follows.
Example 172 [4- (3-CHLORO-5-HYDROXYMETHYL-PYRIDIN-2-YL)-1- [5-TRIFLUOROMETHYL-7- (3,] 4,5- [TRIFLUORO-PHENYL)-LH-BENZOIMIDAZOL-2-YL]-PIPERAZINE-2-CARBOXYLIC ACID] methylamide. (a) Piperazine-1,2, 4-tricarboxylic acid 1,4-dibenzyl ester. Benzyl chloro formate (3.1 mL, 22 mmol, Aldrich) was added dropwise over a period of 5 min to a mixture of piperazine-2-carboxylic acid dihydrochloride (2.03 g, 10 mmol, Aldrich) and [NA2C03] (4.24 g, 40 mmol) in water (10 mL) with stirring at [0 C.] The mixture was stirred at [0 C] for 1 h, 2N [HC1] (10 mL) was added and the mixture was extracted with EtOAc (3 x 40 mL). The combined organic extracts were washed with water (10 mL) and brine (20 mL), dried over Na2S04, and filtered. The filtrate was evaporated in vacuo to give the title compound as a gum, which was used for the next step without additional purification. MS (ESI, pos. ion) m/e: 399 (M+1)., 3022-15-9
3022-15-9 Piperazine-2-carboxylic acid dihydrochloride 2723757, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; AMGEN INC.; WO2004/35549; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics