1235865-77-6, 2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4′-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of 2-((1 H-pyrrolo[2,3 -b]pyridin-5 -yl)oxy)-4-(4-((4?-chloro-S,S- dimethyl-3 ,4,5 ,6-tetrahydro- [1,1 ?-biphenyl] -2-yl)methyl)piperazin-1 -yl)benzoic acid (1-1 b) (0.010 g, 0.02 mmol), (S)-2-(morpholinomethyl)-7-nitroindoline-5 -sulfonamide (1-la) (6.7 mg, 0.02 mmol), EDCT (0.011 g, 0.06 mmol), Et3N (6.0 mg, 0.06 mmol) and DMAP (8.0 mg, 0.06 mmol) in DCM (4 mL) was stirred at 30C for 20 h. The mixture was extracted by DCM (25 mL), washed with brine (15 mL), dried with Na2SO4 and concentrated. The residue was purified by preparative TLC eluting with DCM / MeOH (15:1) to give the title compound (S)-2-((1H-pyrrolo[2,3 -b]pyridin-5 -yl)oxy)-4-(4-((4?-chloro-5,5-dimethyl-3 ,4,5,6-tetrahydro-[1 , 1?-biphenyl] -2-yl)methyl)piperazin- 1 -yl)-N-((2-(morpholinomethyl)-7-nitroindolin-5 -yl)sulfonyl)b enzamide (1-1). MS-ESI (m/z): 895 [M+ 1]., 1235865-77-6
The synthetic route of 1235865-77-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SHANGHAI FOCHON PHARMACEUTICAL CO., LTD.; FOCHON PHARMACEUTICALS, LTD.; LIU, Hongbin; RONG, Yue; ZHANG, Huajie; CHEN, Zhifang; TAN, Rui; HE, Chengxi; LI, Zhifu; ZHOU, Zuwen; TAN, Haohan; RAN, Kai; WANG, Xianlong; ZOU, Zongyao; JIANG, Lihua; LIU, Yanxin; ZHAO, Xingdong; WANG, Weibo; (173 pag.)WO2018/192462; (2018); A1;,
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