55112-42-0, 4-Methyl-1-piperazinecarbonyl Chloride Hydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
55112-42-0, EXAMPLE 107: 4-(4-(l,3-BenzothiazoI-6-ylamino)-7fl-pyrrolo[2,3-rf|-pyrimidin-6-yl)methylpiperazinyI-3,6-dihydropyridine-l(2fl)-yI)-carboxamide.; [342] To a suspension of benzothiazol-6-yl-[6-(l ,2,3,6-tetrahydropyridin-4-yl)-7^-pyrrolo[2,3-J]pyrimidin-4-yl]-amine tris-hydrochloride (200mg, 0.44mmol) in NJJ-dimethylformamide (6mL) was added AfAf-diisopropylethylamine (O.SmL, 3mmol). Thereaction mixture was stirred at 0C for 5min prior to the addition of 4-methylpiperazine-l-carbonyl chloride hydrochloride (87mg, 0.44mmol). The resulting mixture was stirred at 0Cfor Ih, diluted with water (50mL), and the resulting precipitate was collected by filtration,washed with EtOAc (5mL), and dried in vacua to give the title compound. LC-MS (ES,Pos.): 474 [MH+], and ‘H NMR (DMSO-d6, 400 MHz): 5 = 1.99 (s, 3H), 2.24 (m, 4H), 2.50(m, 2H), 3.18 (m, 4H), 3.41 (m, 2H), 3.93 (m, 2H), 6.41 (s, IH), 6.82 (s, IH), 7.87 (d, J= 8.8Hz, IH), 8.04 (d, J= 8.8 Hz, IH), 8.34 (s, IH), 8.91 (s, IH), 9.23 (s, IH), 9.59 (s, IH), 11.99(s, IH).
The synthetic route of 55112-42-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; OSI PHARMACEUTICALS, INC.; WO2006/17443; (2006); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics