149057-19-2, 4-((Benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Stage 1. 4-Benzyl 1 ,2-di-teit-butyl piperazine-1 ,2,4-tricarboxylate 4-[(Benzyloxy)carbonyl]- 1 -(teit-butoxycarbonyl)piperazi ne-2-carboxyl ic acid (1.0 g,2.74 mmol) was dissolved in toluene (10 mL) and heated to 80C under a nitrogen atmosphere. DMF di teit-butyl acetal was then added dropwise (2.6 mL, 11 mmol) and stirring continued for 2 hrs. The reaction mixture was cooled and partitioned between EtOAc (200 mL) and water (200 mL). The organic layer was separated and the aqueous layer re-extracted with EtOAc (2 x 100 mL). The combined organic layers were dried over Mg504, concentrated in vacuo and the residue was purified by automated column chromatography (0-100% EtOAc/heptane) to give the title compound as a colourless oil (1.08 g, 94%).LCMS: m/z 443 [M+Na]., 149057-19-2
149057-19-2 4-((Benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid 2756778, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; CHROMA THERAPEUTICS LTD; DAVIES, Stephen John; PINTAT, Stephane; NORTH, Carl Leslie; MOFFAT, David Festus Charles; WO2014/1802; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics