With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.74879-18-8,(S)-(+)-2-Methylpiperazine,as a common compound, the synthetic route is as follows.
74879-18-8, Example 189: Synthesis of 4-Chloro-6-[2-((R)-3-methyl-piperazin-l-yl)-benzyl amino]-4a,8a-dihydro-2H-phthalazin-l-one; 2-((R)-3-Methyl-piperazin-l-yl)-benzonitrile; A mixture 2-bromobenzonitrile (1.0 g, 5.494 mmol), (S)-(+)-2-methylpiperazine(0.60 g, 5.99 mmol), Pd2(dba)3 (0.503 g, 0.549 mmol), rac-BINAP (1.026 g, 1.648 mmol) and NaO’Bu (2.11 g, 21.976 mmol) in DMA (27 mL) was heated at 8O0C for 2.5h. The mixture was allowed to cool, diluted with EtOAc and washed with water. The organic layer was washed with sat.aq. NaHCO3, brine and dried (Na2SO4). Chromatography (EtOAc/MeOH) afforded 2-((R)-3 -methyl-piperazin- 1 -yl)-benzonitrile (540 mg) as a white solid. 1H (400 MHz, d6-DMSO) delta: ppm; m/z (M+l) 202.21.
The synthetic route of 74879-18-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; FOREST LABORATORIES HOLDINGS LIMITED; WO2008/61108; (2008); A2;,
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