With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.106261-48-7,4-((4-Methylpiperazin-1-yl)methyl)benzoic acid,as a common compound, the synthetic route is as follows.
[00122] To a solution of 7-(3-amino-phenylamino)-l,3-dihydro-mdol-2-one (80 mg, 0.33 mmol) in DMF (2ml) is added 4-(4-methyl-piperazin-l-ylmethyl)-benzoic acid (113 mg, 0.37 mmol), N,N-diisopropylethylamine (0.22 g, 1.67 mmol) and HATU (0.14 g, 0.37 mmol). The reation is stirred for 12 hours and concentrated. The residue is purified by HPLC to afford the desired compound: LC-MS: 456.2 (MH+).
106261-48-7, The synthetic route of 106261-48-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; IRM LLC; WO2006/52936; (2006); A2;,
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