With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.120737-78-2,tert-Butyl 2-methylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
120737-78-2, General Procedure: To a round bottom flask equipped with a stir bar were added l-bromo-2- chloro-4-fluoro benzene (0.314 g, 1.5 mmol), 2-methyl-piperazine-l-carboxylic acid tert-butyl ester (0.451 g, 2.25 mmol), sodium tert-butoxide (0.216 g, 2.25 mmol) and toluene (15 mL). The reaction mixture was heated to 80 C and then a mixture of tris(dibenzylidine acetone)dipalladium (31.1 mg, 0.015 mmol) and racemic 2,2′-bis(diphenylphosphino)-l,l’- binaphthyl (13.7 mg, 0.05 mmol) in toluene (2 mL) was slowly added to the reaction mixture. The reaction mixture was stirred at 110 C overnight and then concentrated in vacuo. The residue was dissolved in ethyl acetate (100 mL) and washed with water (3 x 50 mL) and brine (50 mL). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The crude residue was purified on silica gel using hexanes:diethyl ether = 100:0 to 80:20 in a gradient fashion, to give the desired product (147.9 mg, 28 %). 1H
120737-78-2 tert-Butyl 2-methylpiperazine-1-carboxylate 15087784, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2007/87135; (2007); A2;,
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