115619-01-7, 4-(4-Ethylpiperazin-1-yl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of 5 (0.16g, 0.77mmol), H2O (0.4ml) and AcOH (1.6ml) was mixed with the 84 (0.22g, 1.00mmol) and then refluxed for overnight. The reaction was quenched by saturated NaHCO3 (aq.) and the mixture was extracted by ethyl acetate (30ml x 3). The residue was purified by flash column over silica gel (dichloromethane: methanol = 9: 1, Rf = 0.35) to afford 88 (0.22g, 73.54%) as a pale yellow solid. 1H-NMR (500MHz, CDCl3): 5 1.16 (t, J= 7.5 Hz, 3H), 2.52 (q, J= 7.5 Hz, 2H), 2.66 (t, J= 5.0 Hz, 4H), 2.88 (d, J= 5.0 Hz, 3H), 3.25 (t, J= 5.0 Hz, 4H), 4.84 (s, 1H), 5.51 (s, 1H), 6.51 (s, 1H), 6.95 (d, J= 8.5 Hz, 2H), 7.23 (d, J= 8.5 Hz, 2H), 7.42-7.43 (m, 3H), 8.31-8.33 (m, 2H).
115619-01-7, As the paragraph descriping shows that 115619-01-7 is playing an increasingly important role.
Reference£º
Patent; TAIPEI MEDICAL UNIVERSITY; YEN, Yun; LIOU, Jing-Ping; CHEN, Chun-Han; (70 pag.)WO2017/15400; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics