373608-48-1, tert-Butyl 4-(3-aminopropyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: A stock solution was prepared containing 2-benzyl-6-(methylcarbamoyl)isonicotinic acid (162 mg) plus HATU (228 mg) dissolved together in DMF (3 mL). DIPEA (330 mu) was added and the vials capped and shaken to aid dissolution. An aliquot of this reaction mixture (0.5 mL, 0.1 mmol) was added to a set of preweighed amines with the structures shown above (0.12 mmol) in matrix vials (1.2 mL). The vials were capped and shaken to disperse the contents and stood at rt for 18 h. The samples were injected (0.6 mL) as is and purified by MDAP (High pH). The solvent was dried under a stream of N2 to give the required product. (1230) BOC deprotection of example 11: the Boc-protected intermediate was redissolved in 4 N HCI/l,4-dioxane (0.5 mL) and DCM (0.5 mL) was added. The vial was capped and stood at rt for 1 h. The solvent was removed to dryness to afford Example 11 as its HCI salt.
373608-48-1, As the paragraph descriping shows that 373608-48-1 is playing an increasingly important role.
Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; ATKINSON, Stephen John; DEMONT, Emmanuel Hubert; HARRISON, Lee Andrew; LEVERNIER, Etienne; PRESTON, Alexander G; SEAL, Jonathan Thomas; WALL, Ian David; WATSON, Robert J; WOOLVEN, James Michael; (225 pag.)WO2017/174621; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics