With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.548762-66-9,(2S,5R)-tert-Butyl 2,5-dimethylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
548762-66-9, To a stirred solution of 8.736 g (40.76 mmol) tert-butyl (2S,5R)-2,5-dimethylpiperazine-1 – carboxylate in 30 mL DCM were added at RT 21 .30 mL DIPEA (122.29 mmol, 3 eq) and 13 g 3-fluorobenzenesulfonyl chloride (61.15 mmol, 1 .5 eq) and the mixture was stirred overnight at RT. The organic phase was washed three times with water, dried and evaporated to yield 15.91 g (100%) of the crude title compound which was used in the next step without further purification. (0544) LC-MS (Method 1 ): Rt = 1.37 min; MS (ESIpos): m/z = 391 [M+H]+ (0545) 1H-NMR (400 MHz, DMSO-d6) delta [ppm]: 0.870 (2.76), 0.978 (2.40), 1 .374 (16.00), 2.518 (0.96), 2.523 (0.65), 3.176 (0.83), 3.207 (0.88), 3.360 (2.07), 3.391 (1 .29), 3.581 (0.47), 4.101 (0.61 ), 7.548 (2.26), 7.553 (3.33), 7.556 (2.41 ), 7.565 (2.95), 7.570 (2.61 ), 7.641 (0.55), 7.647 (1.00), 7.653 (0.57), 7.664 (1.16), 7.670 (1 .98), 7.676 (1 .05), 7.687 (0.57), 7.693 (0.96), 7.699 (0.50).
As the paragraph descriping shows that 548762-66-9 is playing an increasingly important role.
Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; KOPPITZ, Marcus; SIEBENEICHER, Holger; STEUBER, Holger; TER LAAK, Antonius; NUBBEMEYER, Reinhard; ROTTMANN, Antje; IRLBACHER, Horst; BADER, Benjamin; PETERS, Michaele; WAGENFELD, Andrea; (157 pag.)WO2018/114670; (2018); A1;,
Piperazine – Wikipedia
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