109-01-3, 1-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Add 10 g (46.3 mmol) of p-nitrobenzyl bromide and 100 mL of dichloromethane to a 500 mL single-necked flask. A mixture of 4.7 g (47.0 mmol) of N-methylpiperazine and 7.1 g (70.3 mmol) of triethylamine in 20 mL of dichloromethane was slowly added dropwise under ice-water bath (0-5 C). After heating and refluxing for 1 hr, the material disappeared by TLC (ethyl acetate: petroleum ether = 1:2). 150 mL of chloroform and 100 mL of a saturated sodium hydrogencarbonate solution were added to the reaction mixture, and stirred vigorously at room temperature for 30 min. The reaction mixture was extracted with chloroform (100 mL¡Á3), and the organic layers were combined and washed with water and saturated sodium chloride (100 mL¡Á1). Dry over anhydrous magnesium sulfate, filter, The solvent was evaporated under reduced pressure to give 8.5 g of pale yellow solid. The yield was 78.1%, and the product was directly fed to the next reaction without further purification., 109-01-3
As the paragraph descriping shows that 109-01-3 is playing an increasingly important role.
Reference£º
Patent; Shanghai Fuxing Pharmaceutical Industrial Co., Ltd.; Lu Shuai; Jin Qiaomei; Wang Yue; Chen Yadong; Lu Tao; (54 pag.)CN104592251; (2019); B;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics