120737-59-9, tert-Butyl 3-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a stirred solution of 135 1-fluoro-4-nitrobenzene (5.0 g, 35.46 mmol, 1.0 eq) and 248 tert-butyl 3-methylpiperazine-1-carboxylate (7.09 g, 35.46 mmol, 1.0 eq) in 95 DMSO (40 mL) was added 64 K2CO3 (9.78 g, 70.92 mmol, 2.0 eq). The reaction mixture was heated at 120¡ã C. for 16 h. Progress of the reaction was monitored by LCMS. Upon the consumption of starting material, mixture was diluted with water (100 mL) and extracted with ethyl acetate (200 mL¡Á2). Combined organic layer was washed with water (50 mL¡Á3), dried over anhydrous Na2SO4 and concentrated under reduced pressure. Crude residue was purified by flash chromatography using 19 ethyl acetate: 20 hexane as eluents to obtain 249 tert-butyl 3-methyl-4-(4-nitrophenyl)piperazine-1-carboxylate (5.5 g, 48.67percent). (0378) LCMS: 322 [M+1]+, 120737-59-9
The synthetic route of 120737-59-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; giraFpharma LLC; Chakravarty, Sarvajit; PHAM, Son Minh; Kankanala, Jayakanth; AGARWAL, Anil Kumar; PUJALA, Brahmam; SONI, Sanjeev; ARYA, Satish K.; PALVE, Deepak; KUMAR, Varun; (360 pag.)US2019/106436; (2019); A1;,
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