With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55112-42-0,4-Methyl-1-piperazinecarbonyl Chloride Hydrochloride,as a common compound, the synthetic route is as follows.
55112-42-0, Example 6: Preparation of Zopiclone in ACN[0069] To a slurry of l-chlorocarbonyl-4-methyl piperazine hydrochloride(CMP) (4.92g) in acetonitrile (ACN) (75 ml), stirred mechanically at Room temperature and under nitrogen, was added tri-ethyl amine (Et^N) (4.42g). After Et3N addition ended, DMAP (0.46g) was added to the slurry, and after 1-2 min of stirring, 7-OH -Py (5g) was added. The slurry changed its appearance at 7-OH addition. The stirring was applied for 2h at about 00C, then at room temperature for 14h.The reaction was completed after an additional heating (about 9h) at 400C. After cooling to the room temperature the solvent was evaporated, to give a yellowish-brown solid, that was dissolved in CH2CI2 (40 ml) and water (50 ml). Phases were separated while the interphase was left in the aqueous phase. The aqueous phase was extracted with CH2CI2 (40 ml). The combined organic phases were washed with water (50 ml), dried over MgSO4 filtered and evaporated to dryness to give zopiclone crude product (6.17g, yield 82.2%; purity 98.24% by HPLC).
The synthetic route of 55112-42-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.; WO2008/2629; (2008); A1;,
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