4318-42-7, 1-Isopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,4318-42-7
(1H-Indol-5-yl)-(4-isopropyl-piperazin-1-yl)-methanone A mixture of 3.23 g (20 mmol) indole-5-caboxylic acid (commercially available), 3.07 g (24 mmol) 1-(2-propyl)-piperazine (commercially available), 8.03 g (25 mmol) TBTU and 10.3 mL (60 mmol) DIPEA in 50 mL DMF was stirred for 2 h (hours) at room temperature. After evaporation of all volatiles the residue was extracted with ethyl acetate, the combined organic layers dried with MgSO4 and evaporated to dryness. The residue was subsequently purified by flash column chromatography eluding with a mixture formed from DCM, MeOH, and NH3 aq. to yield after evaporation of the combined product fractions 5.1 g (94percent) of the title compound as light brown foam. MS(m/e): 272.3 (MH+).
The synthetic route of 4318-42-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Nettekoven, Matthias Heinrich; Roche, Olivier; US2007/270423; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics