192130-34-0, tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
(i) tert-Butyl 4-(2-(5-(tert-butyl)-2-methoxy-3-(3-(4-((2-(phenylamino)pyridin-4-yl)oxy)- naphthalen-1-yl)ureido)benzamido)ethyl)piperazine-1-carboxylateA stirred mixture of 5-(tert-butyl)-2-methoxy-3-(3-(4-((2-(phenylamino)pyridin-4- yl)oxy)naphthalen-1-yl)ureido)benzoic acid, HCI (see Example 14(iii) above; 80 mg, 0.130 mmol), tert-butyl 4-(2-aminoethyl)piperazine-1-carboxylate (59.8 mg, 0.261 mmol) and triethylamine (72.7 muIota_, 0.522 mmol) in DCM (4 mL) was cooled in an ice-bath. 50 wtpercent T3P in EtOAc (93 muIota_, 0.157 mmol) was added, the ice-bath was removed and the reaction mixture allowed to warm to rt and stirred for 36 h. The reaction mixture was partitioned between sat. aq. NaHCC>3 (10 mL) and DCM (10 mL). The aqueous phase was back extracted with fresh DCM (10 mL). The combined organic extracts were washed with water (20 mL), brine (20 mL), dried (MgSC ), filtered and concentrated in vacuo onto silica gel. The crude product was purified by chromatography on the Companion (12 g column, 1-5percent MeOH in DCM) to afford the sub-title compound (52 mg) as a pink/brown solid.LCMS m/z 788 (M+H)+(ES+); 786 (M-H)”(ES”)
192130-34-0, The synthetic route of 192130-34-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED; FYFE, Matthew Colin Thor; THOM, Stephen Malcolm; BAKER, Thomas Matthew; HARBOTTLE, Gareth William; HASIMBEGOVIC, Vedran; RIGBY, Aaron; WO2015/92423; (2015); A1;,
Piperazine – Wikipedia
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