259808-67-8, 1-Boc-3,3-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of tert-butyl 3,3- dimethylpiperazine-l-carboxylate (150 mg, 0.70 mmol) in dichloromethane (5 mL) was added 3- (2,6-dichlorophenyl)-5-(propan-2-yl)-l,2-oxazole-4-carbaldehyde (180 mg, 0.63 mmol) and sodium acetate (87 mg, 1.06 mmol). The mixture was stirred for 1 h at room temperature. Then STAB (404 mg, 1.91 mmol) was added. The resulting solution was stirred overnight at room temperature. The reaction was then quenched by adding water (15 mL). The resulting mixture was extracted with 5×5 mL of dichloromethane and the organic layers were combined. The organic phase was washed successively with water and brine. The residue was concentrated under vacuum after dried over anhydrous sodium sulfate. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (1 : 10). This resulted in 0.116 g (38%) of the title compound as a white solid. LC-MS (ESI, m/z): [M+H]+ = 482.4.
259808-67-8, The synthetic route of 259808-67-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; HEPAGENE THERAPEUTICS, INC.; XU, Xiaodong; (104 pag.)WO2018/85148; (2018); A1;,
Piperazine – Wikipedia
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