With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.68104-63-2,4-(Piperazin-1-yl)benzonitrile,as a common compound, the synthetic route is as follows.,68104-63-2
Step B 4-(4-ethyl)piperazinylbenzonitrile Under a nitrogen atmosphere, a stirred solution of 3.16 grams (0.017 mole) of 4-piperazinylbenzonitrile, 2.0 mL (0.025 mole) of iodoethane (available from Aldritch Chemical Company), and 7.1 mL (0.051 mole) of triethylamine in 50 mL of THF was heated at reflux for about three hours. At the conclusion of this period, the reaction mixture was allowed to cool to ambient temperature and 100 mL of water was added. The resulting solution was extracted with two 50 mL portions of diethyl ether. The combined extracts were washed with 100 mL portion of water, dried with sodium sulfate, and filtered. The filtrate was concentrated under reduced pressure, yielding 3,2 grams of crude product. The crude product was purified by column chromatography on silica gel, yielding 2.9 grams of tilte compound. The NMR spectrum was consistent with the proposed structure.
68104-63-2 4-(Piperazin-1-yl)benzonitrile 2733995, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; Theodoridis, George; Barron, Edward; Cohen, Daniel H.; Crawford, Ellen M.; Cullen, Thomas G.; Qi, Hongyan; Rowley, Elizabeth; Ali, Syed F.; Yeager, Walter H.; Duggan, Christina B.; US2002/183342; (2002); A1;,
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