With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5271-27-2,1-Methyl-3-phenylpiperazine,as a common compound, the synthetic route is as follows.
Compound 6 (0.20 g, 1.02 mmol), 1-methyl-3-phenylpiperazine (0.22 g, 1.22 mmol) obtained in the above,Ethyl-3- (3-dimethylaminopropyl) carbodiimide (0.39 g, 2.04 mmol),1-hydroxybenzotriazole (0.13 g, 1.02 mmol), 1-hydroxybenzotriazoleN, N-diisopropylethylamine (0.18 mL, 1.02 mmol) and N, N-diisopropylethylamineThe mixture of 4 mL of solvent DMF was mixed well at the same time while performing a microwave irradiation (Biotage Initiator) at 120 ¡ã C for 3 hours. The mixture was concentrated under reduced pressure, And purified by MPLC (Biotage SNAP Cartridge KP-C18-HS column) to obtain Compound 1 at a yield of 27percent. Rf = 0.32 (8: 2 ethyl acetate: hexane)., 5271-27-2
As the paragraph descriping shows that 5271-27-2 is playing an increasingly important role.
Reference£º
Patent; Keimyung University; Industrial Cooperation Foundation CHONBUK NATIONAL UNIVERSITY; Seo Yeong-ho; Kim Won-il; Kim Beom-seok; Cho Ho-seong; Lee Sang-myeong; (12 pag.)KR101789269; (2017); B1;,
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